Association between Serum Ferritin and Osteocalcin as a Potential Mechanism Explaining the Iron-Induced Insulin Resistance

Autor según el artículo: Juanola-Falgarona, Marti; Candido-Fernandez, Jose; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel A; Estruch, Ramon; Fiol, Miquel; Arija-Val, Victoria; Bullo, Monica

Departamento: Bioquímica i Biotecnologia; Ciències Mèdiques Bàsiques

Autor/es de la URV: Arija Val, Maria Victoria / Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / Fernández Sáez, José / IBARROLA JURADO, NURIA / Salas Salvadó, Jorge

Palabras clave: Zero hunger

Resumen: Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood. Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.To analyzed the associations between serum total and uncarboxylated osteocalcin and adiponectin concentrations with serum ferritin and soluble transferrin receptor (sTfR) in elderly subjects.We evaluated a total of 423 subjects from the PREDIMED cohort in a population-based cross-sectional analysis. Extensive clinical, nutritional and laboratory measurements, including total and uncarboxylated osteocalcin, adiponectin, ferritin and sTfR were recorded.Serum ferritin was positively correlated with increased glucose and insulin circulating levels but also with HOMA-IR, and was inversely associated with total osteocalcin and adiponectin. A regression analysis revealed that serum ferritin and transferrin receptor levels were significantly associated with a decrease in total and uncarboxylated osteocalcin. Serum sTfR levels were associated with lower uncarboxylated osteocalcin levels in the whole-study subjects and remained significant only in the IFG (impaired fasting glucose) individuals.We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.Controlled-Trials.com ISRCTN35739639 <http://www.controlled-trials.com/ISRCTN35739639>.

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Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Direcció de correo del autor: jose.fernandezs@urv.cat; josep.basora@urv.cat; andres.diaz@urv.cat; jose.fernandezs@urv.cat; monica.bullo@urv.cat; josep.basora@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat; victoria.arija@urv.cat

Fecha de alta del registro: 2025-03-22

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076433

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Plos One. 8 (10): e76433-e76433

Referencia de l'ítem segons les normes APA: Juanola-Falgarona, Marti; Candido-Fernandez, Jose; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel A; Estruch, Ramon; Fiol, Miquel; Arija-Val, Victori (2013). Association between Serum Ferritin and Osteocalcin as a Potential Mechanism Explaining the Iron-Induced Insulin Resistance. Plos One, 8(10), e76433-e76433. DOI: 10.1371/journal.pone.0076433

DOI del artículo: 10.1371/journal.pone.0076433

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2013

Tipo de publicación: Journal Publications