Autor según el artículo: Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Salas Salvadó, Jorge

Palabras clave: Predictors Platelet Olive oil Mediterranean diet Mediterranean diet High-density-lipoprotein Fibrinogen Events Disease D-dimer Clinical trials Clinical trial Cardiovascular risk Biomarkers Biomarker Atherothrombosis Adherence

Resumen: To assess whether following a Mediterranean diet (MedDiet) improved atherothrombosis biomarkers in high cardiovascular risk individuals.In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119). We also studied whether large increments in MedDiet adherence (?3 score points, relative to compliance decreases) and intake changes in key food items were associated with 1-year differences in biomarkers. We observed differences between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in HDLs (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound ?1 -antitrypsin levels (-6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake were linked to beneficial changes in atherothrombosis biomarkers.Following a MedDiet improved atherothrombosis biomarkers in high cardiovascular risk individuals. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Direcció de correo del autor: jordi.salas@urv.cat

Identificador del autor: 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/submittedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000350

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (2000350): e2000350-e2000350

Referencia de l'ítem segons les normes APA: Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós (2020). Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research, 64(2000350), e2000350-e2000350. DOI: 10.1002/mnfr.202000350

DOI del artículo: 10.1002/mnfr.202000350

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications