Autor según el artículo: Hernaez, Alvaro; Castaner, Olga; Tresserra-Rimbau, Anna; Pinto, Xavier; Fito, Montserrat; Casas, Rosa; Martinez-Gonzalez, Miguel Angel; Corella, Dolores; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Ros, Emilio; Estruch, Ramon
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Salas Salvadó, Jorge
Palabras clave: Predictors; Platelet; Olive oil; Mediterranean diet; Mediterranean diet; High-density-lipoprotein; Fibrinogen; Events; Disease; D-dimer; Clinical trials; Clinical trial; Cardiovascular risk; Biomarkers; Biomarker; Atherothrombosis; Adherence
Resumen: To assess whether following a Mediterranean diet (MedDiet) improved atherothrombosis biomarkers in high cardiovascular risk individuals.In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119). We also studied whether large increments in MedDiet adherence (?3 score points, relative to compliance decreases) and intake changes in key food items were associated with 1-year differences in biomarkers. We observed differences between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in HDLs (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound ?1 -antitrypsin levels (-6.1% [-11.8; -0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (-9.3% [-18.1; -0.53]). Large MedDiet adherence increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake were linked to beneficial changes in atherothrombosis biomarkers.Following a MedDiet improved atherothrombosis biomarkers in high cardiovascular risk individuals. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
Áreas temáticas: Saúde coletiva; Química; Nutrição; Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Food science & technology; Food science; Farmacia; Educação física; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biotechnology; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Direcció de correo del autor: jordi.salas@urv.cat
Fecha de alta del registro: 2025-02-18
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000350
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (2000350): e2000350-e2000350
Referencia de l'ítem segons les normes APA: Hernaez, Alvaro; Castaner, Olga; Tresserra-Rimbau, Anna; Pinto, Xavier; Fito, Montserrat; Casas, Rosa; Martinez-Gonzalez, Miguel Angel; Corella, Dolor (2020). Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research, 64(2000350), e2000350-e2000350. DOI: 10.1002/mnfr.202000350
DOI del artículo: 10.1002/mnfr.202000350
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV