Autor según el artículo: Aragonès G; Alonso-Villaverde C; Oliveras-Ferraros C; Beltrán-Debón R; Rull A; Rodríguez-Sanabria F; Camps J; Martín A; Menéndez J; Joven J
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA
Palabras clave: Peace, justice and strong institutions
Resumen: Fatty acid synthase (FASN) is an enzyme synthesized by the liver and plays an important role in lipogenesis. The present study aimed to investigate whether serum FASN concentration may provide a direct link between HIV and/or HCV viral infections and lipid metabolic disorders commonly observed in HIV/HCV-infected patients.We evaluated serum FASN concentration in 191 consecutive HIV-infected patients in the absence or presence of HCV co-infection. For comparison, 102 uninfected controls were included. Metabolic and inflammatory phenotype was also compared with respect to the presence of HCV co-infection.Serum FASN concentration was significantly higher in HIV-infected patients than in healthy participants and HCV co-infected patients showed higher levels than those without co-infection. Levels were also affected by treatment regimen, but marginally influenced by virological variables. Insulin concentration was the sole variable among metabolic parameters that demonstrated a significant correlation with serum FASN concentrations. Serum alanine aminotransferase (ALT) values correlated significantly with serum FASN concentration and provided the best discrimination with respect to the presence or absence of HCV co-infection. In multivariate analysis, only ALT, monocyte chemoattractant protein-1 (MCP-1) and the presence of antiretroviral treatment regimen significantly contributed to explain serum FASN concentration in HIV/HCV co-infected patients.Serum FASN concentration is significantly increased in HIV-infected individuals. The release of FASN into the circulation is further enhanced in patients who are co-infected with HCV. Subsequent studies should explore the usefulness of this indicator to monitor the effect of viral infections on disease progression and survival.
Áreas temáticas: Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Gastroenterology & hepatology Gastroenterology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade Antropologia / arqueologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1471230X
Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-9691-1906
Fecha de alta del registro: 2024-11-16
Volumen de revista: 10
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-92
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Bmc Gastroenterology. 10 (92): 92-
Referencia de l'ítem segons les normes APA: Aragonès G; Alonso-Villaverde C; Oliveras-Ferraros C; Beltrán-Debón R; Rull A; Rodríguez-Sanabria F; Camps J; Martín A; Menéndez J; Joven J (2010). Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: Evidence for a novel indicator of viral infection. Bmc Gastroenterology, 10(92), 92-. DOI: 10.1186/1471-230X-10-92
DOI del artículo: 10.1186/1471-230X-10-92
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2010
Tipo de publicación: Journal Publications