Articles producció científica> Medicina i Cirurgia

Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: Evidence for a novel indicator of viral infection

  • Datos identificativos

    Identificador: imarina:840451
    Autores:
    Aragonès GAlonso-Villaverde COliveras-Ferraros CBeltrán-Debón RRull ARodríguez-Sanabria FCamps JMartín AMenéndez JJoven J
    Resumen:
    Fatty acid synthase (FASN) is an enzyme synthesized by the liver and plays an important role in lipogenesis. The present study aimed to investigate whether serum FASN concentration may provide a direct link between HIV and/or HCV viral infections and lipid metabolic disorders commonly observed in HIV/HCV-infected patients.We evaluated serum FASN concentration in 191 consecutive HIV-infected patients in the absence or presence of HCV co-infection. For comparison, 102 uninfected controls were included. Metabolic and inflammatory phenotype was also compared with respect to the presence of HCV co-infection.Serum FASN concentration was significantly higher in HIV-infected patients than in healthy participants and HCV co-infected patients showed higher levels than those without co-infection. Levels were also affected by treatment regimen, but marginally influenced by virological variables. Insulin concentration was the sole variable among metabolic parameters that demonstrated a significant correlation with serum FASN concentrations. Serum alanine aminotransferase (ALT) values correlated significantly with serum FASN concentration and provided the best discrimination with respect to the presence or absence of HCV co-infection. In multivariate analysis, only ALT, monocyte chemoattractant protein-1 (MCP-1) and the presence of antiretroviral treatment regimen significantly contributed to explain serum FASN concentration in HIV/HCV co-infected patients.Serum FASN concentration is significantly increased in HIV-infected individuals. The release of FASN into the circulation is further enhanced in patients who are co-infected with HCV. Subsequent studies should explore the usefulness of this indicator to monitor the effect of viral infections on disease progression and survival.
  • Otros:

    Autor según el artículo: Aragonès G; Alonso-Villaverde C; Oliveras-Ferraros C; Beltrán-Debón R; Rull A; Rodríguez-Sanabria F; Camps J; Martín A; Menéndez J; Joven J
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA
    Palabras clave: Peace, justice and strong institutions
    Resumen: Fatty acid synthase (FASN) is an enzyme synthesized by the liver and plays an important role in lipogenesis. The present study aimed to investigate whether serum FASN concentration may provide a direct link between HIV and/or HCV viral infections and lipid metabolic disorders commonly observed in HIV/HCV-infected patients.We evaluated serum FASN concentration in 191 consecutive HIV-infected patients in the absence or presence of HCV co-infection. For comparison, 102 uninfected controls were included. Metabolic and inflammatory phenotype was also compared with respect to the presence of HCV co-infection.Serum FASN concentration was significantly higher in HIV-infected patients than in healthy participants and HCV co-infected patients showed higher levels than those without co-infection. Levels were also affected by treatment regimen, but marginally influenced by virological variables. Insulin concentration was the sole variable among metabolic parameters that demonstrated a significant correlation with serum FASN concentrations. Serum alanine aminotransferase (ALT) values correlated significantly with serum FASN concentration and provided the best discrimination with respect to the presence or absence of HCV co-infection. In multivariate analysis, only ALT, monocyte chemoattractant protein-1 (MCP-1) and the presence of antiretroviral treatment regimen significantly contributed to explain serum FASN concentration in HIV/HCV co-infected patients.Serum FASN concentration is significantly increased in HIV-infected individuals. The release of FASN into the circulation is further enhanced in patients who are co-infected with HCV. Subsequent studies should explore the usefulness of this indicator to monitor the effect of viral infections on disease progression and survival.
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Gastroenterology & hepatology Gastroenterology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1471230X
    Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-9691-1906
    Fecha de alta del registro: 2024-11-16
    Volumen de revista: 10
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-92
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Bmc Gastroenterology. 10 (92): 92-
    Referencia de l'ítem segons les normes APA: Aragonès G; Alonso-Villaverde C; Oliveras-Ferraros C; Beltrán-Debón R; Rull A; Rodríguez-Sanabria F; Camps J; Martín A; Menéndez J; Joven J (2010). Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: Evidence for a novel indicator of viral infection. Bmc Gastroenterology, 10(92), 92-. DOI: 10.1186/1471-230X-10-92
    DOI del artículo: 10.1186/1471-230X-10-92
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2010
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Gastroenterology,Gastroenterology & Hepatology,Medicine (Miscellaneous)
    Peace, justice and strong institutions
    Saúde coletiva
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Gastroenterology & hepatology
    Gastroenterology
    Farmacia
    Engenharias iv
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Antropologia / arqueologia
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