Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Unravelling the metabolic alterations of liver damage induced by thirdhand smoke

  • Datos identificativos

    Identificador: imarina:9138882
    Handle: http://hdl.handle.net/20.500.11797/imarina9138882
  • Autores:

    Torres S
    Samino S
    Ràfols P
    Martins-Green M
    Correig X
    Ramírez N
  • Otros:

    Autor según el artículo: Torres S; Samino S; Ràfols P; Martins-Green M; Correig X; Ramírez N
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Correig Blanchar, Francesc Xavier / Ràfols Soler, Pere / Ramírez González, Noelia / SAMINO GENÉ, SARA
    Palabras clave: Thirdhand smoke Nmr-based metabolomics Nafld Mass spectrometry imaging Liver damage Lc-based metabolomics
    Resumen: © 2020 The Author(s) Background: Thirdhand smoke (THS) is the accumulation of tobacco smoke gases and particles that become embedded in materials. Previous studies concluded that THS exposure induces oxidative stress and hepatic steatosis in liver. Despite the knowledge of the increasing danger of THS exposure, the metabolic disorders caused in liver are still not well defined. Objectives: The aim of this study is to investigate the metabolic disorders caused by THS exposure in liver of male mice and to evaluate the effects of an antioxidant treatment in the exposed mice. Methods: We investigated liver from three mice groups: non-exposed mice, exposed to THS in conditions that mimic human exposure and THS-exposed treated with antioxidants. Liver samples were analyzed using a multiplatform untargeted metabolomics approach including nuclear magnetic resonance (1H NMR), liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and laser desorption/ionization mass spectrometry imaging (MSI), able to map lipids in liver tissues. Results: Our multiplatform approach allowed the annotation of eighty-eight metabolites altered by THS exposure, including amino acids, nucleotides and several types of lipids. The main dysregulated pathways by THS exposure were D-glutamine and D-glutamate metabolism, glycerophospholipid metabolism and oxidative phosphorylation and glutathione metabolism, being the last two related to oxidative stress. THS-exposed mice also presented higher lipid accumulation and decrease of metabolites involved in the phosphocholine synthesis, as well as choline deficiency, which is related to Non-Alcoholic Fatty Liver Disease and steatohepatitis. Interestingly, the antioxidant treatment of THS-exposed mice reduced the accumulation of some lipids, but could not revert all the metabolic alterations, including some related to the impairment of the mitochondrial function. Conclusions: THS alters liver function at a molecular level, dysregulating many metabolic pathways. The molecular evidences provided here confirm that THS is a new factor for liver steatosis and provide the basis for future research in this respect.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Medicina iii Medicina ii Medicina i Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Engenharias iv Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0160-4120
    Direcció de correo del autor: xavier.correig@urv.cat noelia.ramirez@urv.cat pere.rafols@urv.cat
    Identificador del autor: 0000-0002-6902-3054 0000-0002-9240-4058
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0160412020321978
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Environment International. 146 (106242): 106242-
    Referencia de l'ítem segons les normes APA: Torres S; Samino S; Ràfols P; Martins-Green M; Correig X; Ramírez N (2021). Unravelling the metabolic alterations of liver damage induced by thirdhand smoke. Environment International, 146(106242), 106242-. DOI: 10.1016/j.envint.2020.106242
    DOI del artículo: 10.1016/j.envint.2020.106242
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Environmental Science (Miscellaneous),Environmental Sciences
    Thirdhand smoke
    Nmr-based metabolomics
    Nafld
    Mass spectrometry imaging
    Liver damage
    Lc-based metabolomics
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Engenharias iv
    Engenharias ii
    Engenharias i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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