Articles producció científica> Medicina i Cirurgia

The complex interaction of genetics and delirium: a systematic review and meta-analysis

  • Datos identificativos

    Identificador: imarina:9187124
    Autores:
    Sepulveda, EstebanAdamis, DimitriosFranco, Jose GMeagher, DavidAranda, SelenaVilella, Elisabet
    Resumen:
    The objective is to understand genetic predisposition to delirium. Following PRISMA guidelines, we undertook a systematic review of studies involving delirium and genetics in the databases of Pubmed, Scopus, Cochrane Library and PsycINFO, and performed a meta-analysis when appropriate. We evaluated 111 articles, of which 25 were finally included in the analysis. The studies were assessed by two independent researchers for methodological quality using the Downs and Black Tool and for genetic analysis quality. We performed a meta-analysis of 10 studies of the Apolipoprotein E (APOE) gene, obtaining no association with the presence of delirium (LOR 0.18, 95% CI - 0.10-0.47, p = 0.21). Notably, only 5 out of 25 articles met established criteria for genetic studies (good quality) and 6 were of moderate quality. Seven studies found an association with APOE4, the dopamine transporter gene SCL6A3, dopamine receptor 2 gene, glucocorticoid receptor, melatonin receptor and mitochondrial DNA haplotypes. One genome-wide association study found two suggestive long intergenic non-coding RNA genes. Five studies found no association with catechol-o-methyltransferase, melatonin receptor or several interleukins genes. The studies were heterogenous in establishing the presence of delirium. Future studies with large samples should further specify the delirium phenotype and deepen our understanding of interactions between genes and other biological factors.
  • Otros:

    Autor según el artículo: Sepulveda, Esteban; Adamis, Dimitrios; Franco, Jose G; Meagher, David; Aranda, Selena; Vilella, Elisabet
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Aranda Castel, Selena / FRANCO VÁSQUEZ, JOSÉ GABRIEL / Sepulveda Ramos, Esteban / Vilella Cuadrada, Elisabet
    Palabras clave: Untranslated rna Test retest reliability Systematic review Single nucleotide polymorphism Scopus Retrospective study Restriction fragment length polymorphism Quality control Psycinfo Prospective study Preferred reporting items for systematic reviews and meta-analyses Neurotransmission Mitochondrial dna Middle aged Meta analysis Melatonin receptor Medline Male Interrater reliability Interleukin 8 Interleukin 6 receptor Intensive care unit Intensive care psychosis Humans Human Haplotype Glucocorticoid receptor Genome-wide association study Genetics Genetic predisposition to disease Genetic predisposition Genetic analysis Female Dopamine 2 receptor Disease association Dementia Delirium tremens Delirium Controlled study Confusion Cochrane library Catechol methyltransferase Biomarkers Article Apolipoprotein e4 Apolipoprotein e Amplified fragment length polymorphism Adult
    Resumen: The objective is to understand genetic predisposition to delirium. Following PRISMA guidelines, we undertook a systematic review of studies involving delirium and genetics in the databases of Pubmed, Scopus, Cochrane Library and PsycINFO, and performed a meta-analysis when appropriate. We evaluated 111 articles, of which 25 were finally included in the analysis. The studies were assessed by two independent researchers for methodological quality using the Downs and Black Tool and for genetic analysis quality. We performed a meta-analysis of 10 studies of the Apolipoprotein E (APOE) gene, obtaining no association with the presence of delirium (LOR 0.18, 95% CI - 0.10-0.47, p = 0.21). Notably, only 5 out of 25 articles met established criteria for genetic studies (good quality) and 6 were of moderate quality. Seven studies found an association with APOE4, the dopamine transporter gene SCL6A3, dopamine receptor 2 gene, glucocorticoid receptor, melatonin receptor and mitochondrial DNA haplotypes. One genome-wide association study found two suggestive long intergenic non-coding RNA genes. Five studies found no association with catechol-o-methyltransferase, melatonin receptor or several interleukins genes. The studies were heterogenous in establishing the presence of delirium. Future studies with large samples should further specify the delirium phenotype and deepen our understanding of interactions between genes and other biological factors.
    Áreas temáticas: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Pharmacology (medical) Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iii Engenharias ii Clinical neurology Ciências biológicas ii Ciências biológicas i Biotecnología Biological psychiatry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: esteban.sepulveda@urv.cat elisabet.vilella@urv.cat selena.aranda@estudiants.urv.cat
    Identificador del autor: 0000-0002-1887-5919
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s00406-021-01255-x
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: European Archives Of Psychiatry And Clinical Neuroscience. 271 (5): 929-939
    Referencia de l'ítem segons les normes APA: Sepulveda, Esteban; Adamis, Dimitrios; Franco, Jose G; Meagher, David; Aranda, Selena; Vilella, Elisabet (2021). The complex interaction of genetics and delirium: a systematic review and meta-analysis. European Archives Of Psychiatry And Clinical Neuroscience, 271(5), 929-939. DOI: 10.1007/s00406-021-01255-x
    DOI del artículo: 10.1007/s00406-021-01255-x
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biological Psychiatry,Clinical Neurology,Medicine (Miscellaneous),Pharmacology (Medical),Psychiatry,Psychiatry and Mental Health
    Untranslated rna
    Test retest reliability
    Systematic review
    Single nucleotide polymorphism
    Scopus
    Retrospective study
    Restriction fragment length polymorphism
    Quality control
    Psycinfo
    Prospective study
    Preferred reporting items for systematic reviews and meta-analyses
    Neurotransmission
    Mitochondrial dna
    Middle aged
    Meta analysis
    Melatonin receptor
    Medline
    Male
    Interrater reliability
    Interleukin 8
    Interleukin 6 receptor
    Intensive care unit
    Intensive care psychosis
    Humans
    Human
    Haplotype
    Glucocorticoid receptor
    Genome-wide association study
    Genetics
    Genetic predisposition to disease
    Genetic predisposition
    Genetic analysis
    Female
    Dopamine 2 receptor
    Disease association
    Dementia
    Delirium tremens
    Delirium
    Controlled study
    Confusion
    Cochrane library
    Catechol methyltransferase
    Biomarkers
    Article
    Apolipoprotein e4
    Apolipoprotein e
    Amplified fragment length polymorphism
    Adult
    Saúde coletiva
    Psychiatry and mental health
    Psychiatry
    Psicología
    Pharmacology (medical)
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Engenharias iii
    Engenharias ii
    Clinical neurology
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biological psychiatry
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