Articles producció científica> Medicina i Cirurgia

Elective cancer surgery in Covid-19-free surgical pahtways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

  • Datos identificativos

    Identificador: imarina:9193836
    Handle: https://hdl.handle.net/20.500.11797/imarina9193836
    Autores:
    Glasbey, James C.Nepogodiev, DmitriSimoes, Joana F. F.Omar, OmarLi, ElizabethVenn, Mary L.Abou Chaar, Mohammad K.Capizzi, VitaChaudhry, DaoudDesai, AnantEdwards, Jonathan G.Evans, Jonathan P.Fiore, MarcoVideria, Jose FlavioFord, Samuel J.Ganly, IanGriffiths, Ewen A.Gujjuri, Rohan R.Kolias, Angelos G.Kaafarani, Haytham M. A.Minaya-Bravo, AnaMcKay, Siobhan C.Mohan, Helen M.Roberts, Keith J.San Miguel-Mendez, CarlosPockney, PeterShaw, RichardSmart, Neil J.Stewart, Grant D.Sundar, SudhaVidya, RaghavanBhangu, Aneel A.COVIDSurg Collaborative
    Resumen:
    PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rat

  • Otros:

    Autor según el artículo: Glasbey, James C.; Nepogodiev, Dmitri; Simoes, Joana F. F.; Omar, Omar; Li, Elizabeth; Venn, Mary L.; Abou Chaar, Mohammad K.; Capizzi, Vita; Chaudhry, Daoud; Desai, Anant; Edwards, Jonathan G.; Evans, Jonathan P.; Fiore, Marco; Videria, Jose Flavio; Ford, Samuel J.; Ganly, Ian; Griffiths, Ewen A.; Gujjuri, Rohan R.; Kolias, Angelos G.; Kaafarani, Haytham M. A.; Minaya-Bravo, Ana; McKay, Siobhan C.; Mohan, Helen M.; Roberts, Keith J.; San Miguel-Mendez, Carlos; Pockney, Peter; Shaw, Richard; Smart, Neil J.; Stewart, Grant D.; Sundar, Sudha; Vidya, Raghavan; Bhangu, Aneel A.; COVIDSurg Collaborative
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Jorba Martin, Rosa Maria
    Palabras clave: Surgery
    Resumen: PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
    Áreas temáticas: Saúde coletiva Oncology Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: rosamaria.jorba@urv.cat
    Identificador del autor: 0000-0003-3307-4340
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Clinical Oncology. 39 (1): 66-78
    Referencia de l'ítem segons les normes APA: Glasbey, James C.; Nepogodiev, Dmitri; Simoes, Joana F. F.; Omar, Omar; Li, Elizabeth; Venn, Mary L.; Abou Chaar, Mohammad K.; Capizzi, Vita; Chaudhry (2021). Elective cancer surgery in Covid-19-free surgical pahtways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study. Journal Of Clinical Oncology, 39(1), 66-78. DOI: 10.1200/JCO.20.01933
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Cancer Research,Medicine (Miscellaneous),Oncology
    Surgery
    Saúde coletiva
    Oncology
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Cancer research
    Biotecnología

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