Autor según el artículo: Laguna, Ariadna; Xicoy, Helena; Tolosa, Eduardo; Serradell, Monica; Vilas, Dolores; Gaig, Carles; Fernandez, Manel; Yanes, Oscar; Santamaria, Joan; Amigo, Nuria; Iranzo, Alex; Vila, Miquel
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/es de la URV: Yanes Torrado, Óscar
Palabras clave: Very low density lipoprotein Triacylglycerol Tobacco use Synucleinopathy Sensitivity and specificity Risk assessment Risk Rem sleep Receiver operating characteristic Protein glycosylation Protein fingerprinting Protein Prevalence Predictive value Prediction Pathophysiology Parkinsonism Parasomnia Outcome assessment Obesity Nuclear magnetic resonance spectroscopy Nuclear magnetic resonance Neurologic disease Neurodegeneration Metabolism Markers Management Male Major clinical study Low density lipoprotein Lipoprotein Intermediate density lipoprotein Inflammation Hypertension Human High density lipoprotein Female False discovery rate Dyslipidemia Disease exacerbation Disease Diagnostic test accuracy study Diagnosis Diabetes mellitus Dementia Data analysis Controlled study Comorbidity Cohort analysis Clinical outcome Cholesterol Blood sampling Biological marker Behavior disorder Article Area under the curve Aged
Resumen: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of Lewy-type synucleinopathies (LTS), which can present either with an initial predominant parkinsonism (Parkinson's disease (PD)) or dementia (dementia with Lewy bodies (DLB)). To provide insights into the underlying pathogenic mechanisms, the lipoprotein and protein glycosylation profile of 82 iRBD patients, collected before and/or after their conversion to an overt LTS, and 29 matched control serum samples were assessed by nuclear magnetic resonance (NMR) spectroscopy. Data were statistically analyzed to identify altered metabolites and construct predictive models. Univariant analysis detected no differences between iRBD patients with an LTS compared to controls. However, significant differences were found when the analysis distinguished between iRBD patients that manifested initially predominant parkinsonism (pre-PD) or dementia (pre-DLB). Significant differences were also found in the analysis of paired iRBD samples pre- and post-LTS diagnosis. Predictive models were built and distinguished between controls and pre-DLB patients, and between pre-DLB and pre-PD patients. This allowed a prediction of the possible future clinical outcome of iRBD patients. We provide evidence of altered lipoprotein and glycosylation profiles in subgroups of iRBD patients. Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression of LTS in iRBD patients. Our data also indicate that profiling of serum samples by NMR may be a useful tool for identifying short-term high-risk iRBD patients for conversion to parkinsonism or dementia.
Áreas temáticas: Neurosciences Neurology (clinical) Neurology Cellular and molecular neuroscience
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: oscar.yanes@urv.cat
Identificador del autor: 0000-0003-3695-7157
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41531-021-00184-9
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Npj Parkinsons Dis. 7 (1): 40-
Referencia de l'ítem segons les normes APA: Laguna, Ariadna; Xicoy, Helena; Tolosa, Eduardo; Serradell, Monica; Vilas, Dolores; Gaig, Carles; Fernandez, Manel; Yanes, Oscar; Santamaria, Joan; Am (2021). Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder. Npj Parkinsons Dis, 7(1), 40-. DOI: 10.1038/s41531-021-00184-9
DOI del artículo: 10.1038/s41531-021-00184-9
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications