Autor según el artículo: Muntane, Gerard; Chillida, Marc; Aranda, Selena; Navarro, Arcadi; Vilella, Elisabet;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Aranda Castel, Selena / Muntané Medina, Gerard / Vilella Cuadrada, Elisabet
Palabras clave: White-matter Weighted gene coexpression network analysis Transcriptome Sox10 gene Slc2a5 gene Schizophrenia risk gene Schizophrenia Receptor protein-tyrosine kinases Protein tyrosine kinase Plp1 gene Pdgfra gene Overlapping gene Oligodendroglia Oligodendrocytes Oligodendrocyte related gene Olig2 gene Olig1 gene Neurons Myelination Myelin Microglia type 2 Microglia Microarray analysis Mbp gene Mag gene Humans Human brain Human Genome-wide association study Genetics Gene ontology Gene expression Gene coexpression Gene Gac gene Expression Disorders Discoidin domain receptor 1 Ddr1 Database Cxc3l1 gene Cspg4 gene Col4a1 gene Col1a1 gene Coexpression Cnp gene Cldn11 gene Cd53 gene Brain development Brain Astrocytes Astrocyte Article Analysis
Resumen: Background Discoidin domain receptor tyrosine kinase 1 (DDR1) is present in multiple types of epithelial cells and is highly expressed in the nervous system. Previous studies have revealed that DDR1 is involved in schizophrenia (SCZ). Although the expression of DDR1 in oligodendrocytes has been described, its role in brain myelination is not well understood. In this study, we aimed to explore the coexpression network of DDR1 in the human brain and to compare the list of DDR1 coexpressing genes with the list of genes containing single nucleotide polymorphisms (SNPs) that are associated with SCZ. Materials and Methods We used a weighted gene coexpression network analysis (WGCNA) of a dataset from four brain areas (the dorsolateral prefrontal cortex, primary motor cortex, hippocampus, and striatum) and from four different intervals (I) of life (I-1 = 10-38 weeks postconception, I-2 >= 0 to < 6 years, I-3 >= 6 to < 40 years, and I-4 >= 40 years of age). We compared the list of genes that are associated with SCZ in the GWAS Catalog with the list of genes coexpressing with DDR1 in each interval. Results Our study revealed that DDR1 was coexpressed with oligodendrocyte-related genes mainly in I-2 (adjP = 5.66e-24) and I-3 (adjP = 2.8e-114), which coincided with the coexpression of DDR1 with myelination-related genes (adjP = 9.04e-03 and 2.51e-08, respectively). DDR1 was also coexpressed with astrocyte-related genes in I-1 (adjP = 1.11e-71), I-2 (adjP = 2.12e-20) and I-4 (adjP = 9.93e-52) and with type 2 microglia-related genes in I-1 (adjP = 2.84e-08), I-2 (adjP = 5.68e-16) and I-4 (adjP = 3.66e-10). Moreover, we observed significant enrichment of SCZ susceptibility genes within the coexpression modules containing DDR1 in I-1 and I-4 (P = 1e-04 and 0.0037, respectively), during which the DDR1 module showed the highest association with the astrocytes. Conclusions Our study confirmed that DDR1 is coexpressed with oligodendrocyte- and myelin-related genes in the human brain but suggests that DDR1 may contribute mainly to SCZ risk through its role in other glial cell types, such as astrocytes.
Áreas temáticas: Neurosciences Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iv Ciências biológicas ii Ciências biológicas i Biotecnología Behavioral sciences Behavioral neuroscience
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: gerard.muntane@urv.cat elisabet.vilella@urv.cat selena.aranda@estudiants.urv.cat
Identificador del autor: 0000-0002-1887-5919
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.2309
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Brain And Behavior. 11 (8):
Referencia de l'ítem segons les normes APA: Muntane, Gerard; Chillida, Marc; Aranda, Selena; Navarro, Arcadi; Vilella, Elisabet; (2021). Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain. Brain And Behavior, 11(8), -. DOI: 10.1002/brb3.2309
DOI del artículo: 10.1002/brb3.2309
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV