Autor según el artículo: Zuccarello G; Escofet I; Caniparoli U; Echavarren AM
Departamento: Química Analítica i Química Orgànica
Autor/es de la URV: ECHAVARREN PABLOS, ANTONIO
Palabras clave: Intermolecular 2+2 cycloaddition Gold Cyclization Chiral ligands Asymmetric catalysis Alkynes scalable synthesis phosphine-phosphite-ligands metal-complexes kinetic resolution homogeneous catalysis gold(iii) compounds gold enantioselective synthesis cyclobutane derivatives cyclization complexes synthesis chiral ligands asymmetric catalysis
Resumen: Gold(I) catalysts are ideal for the activation of alkynes under very mild conditions. However, unlike allenes or alkenes, the triple bond of alkynes cannot be prochiral. In addition, the linear coordination displayed by gold(I) complexes places the chiral ligand far away from the substrate resulting in an inefficient transfer of chiral information. This poses a significant challenge for the achievement of high enantiocontrol in gold(I)-catalyzed reactions of alkynes. Although considerable progress on enantioselective gold(I)-catalyzed transformations has recently been achieved, the asymmetric activation of non-prochiral alkyne-containing small molecules still represents a great challenge. Herein we summarize recent advances in intra- and intermolecular enantioselective gold(I)-catalyzed reactions involving alkynes, discussing new chiral ligand designs that lie at the basis of these developments. We also focus on the mode of action of these catalysts, their possible limitations towards a next-generation of more efficient ligand designs. Finally, square planar chiral gold(III) complexes, which offer an alternative to chiral gold(I) complexes, are also discussed.
Áreas temáticas: Química General chemistry Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all)
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: antoniomaria.echavarren@urv.cat
Identificador del autor: 0000-0002-6418-7930
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cplu.202100232
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Chempluschem. 86 (9): 1283-1296
Referencia de l'ítem segons les normes APA: Zuccarello G; Escofet I; Caniparoli U; Echavarren AM (2021). New-Generation Ligand Design for the Gold-Catalyzed Asymmetric Activation of Alkynes. Chempluschem, 86(9), 1283-1296. DOI: 10.1002/cplu.202100232
DOI del artículo: 10.1002/cplu.202100232
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications