Autor según el artículo: Adria-Cebrian, Jose; Guaita-Esteruelas, Sandra; Lam, Eric W -F; Rodriguez-Balada, Marta; Capellades, Jordi; Girona, Josefa; Jimenez-Santamaria, Ana Maria; Yanes, Oscar; Masana, Luis; Guma, Josep
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Adriá Cebrián, Jose / Girona Tell, Josefa / GUAITA ESTERUELAS, SANDRA / Gumà Padró, José / Masana Marín, Luis / RODRÍGUEZ BALADA, MARTA / Yanes Torrado, Óscar
Palabras clave: Tumor-surrounding adipocytes Tumor microenvironment Mass spectrometry Lipids Fabp5 Fabp4 Cd36 Breast Adipocytes tumor microenvironment sphingolipids progression mass spectrometry lipids fabp5 fabp4 cd36 adipocytes
Resumen: Obesity and adipose tissue have been closely related to a poor cancer prognosis, especially in prostate and breast cancer patients. The ability of transferring lipids from the adipose tissue to the tumor cells is actively linked to tumor progression. However, different types of breast tumor seem to use these lipids in different ways and metabolize them in different pathways. In this study we have tracked by mass spectrometry how palmitic acid from the adipocytes is released to media being later incorporated in different breast cancer cell lines (MDA-MB-231, SKBR3, BT474, MCF-7 and its resistant MCF-7 EPIR and MCF-7 TAXR). We have observed that different lines metabolize the palmitic acid in a different way and use their carbons in the synthesis of different new lipid families. Furthermore, we have observed that the lipid synthesis pattern varied according to the cell line. Surprisingly, the metabolic pattern of the resistant cells was more related to the TNBC cell line compared to their sensitive cell line MCF-7. These results allow us to determine a specific lipid pattern in different cell lines that later might be used in breast cancer diagnosis and to find a better treatment according to the cancer molecular type. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Áreas temáticas: Oncology Medicina iii Cancer research
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: josefa.girona@urv.cat oscar.yanes@urv.cat jose.adria@estudiants.urv.cat josefa.girona@urv.cat jose.guma@urv.cat luis.masana@urv.cat
Identificador del autor: 0000-0002-6267-8779 0000-0003-3695-7157 0000-0002-6267-8779 0000-0001-7541-9832 0000-0002-0789-4954
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6694/13/
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Cancers. 13 (23): 5871-
Referencia de l'ítem segons les normes APA: Adria-Cebrian, Jose; Guaita-Esteruelas, Sandra; Lam, Eric W -F; Rodriguez-Balada, Marta; Capellades, Jordi; Girona, Josefa; Jimenez-Santamaria, Ana Ma (2021). Mcf-7 drug resistant cell lines switch their lipid metabolism to triple negative breast cancer signature. Cancers, 13(23), 5871-. DOI: 10.3390/cancers13235871
DOI del artículo: 10.3390/cancers13235871
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications