Articles producció científica> Medicina i Cirurgia

Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk

  • Datos identificativos

    Identificador: imarina:9242341
    Autores:
    Rodríguez-Calvo RMoreno-Vedia JGirona JIbarretxe DMartínez-Micaelo NMerino JPlana NMasana L
    Resumen:
    Background: Liver steatosis is considered the onset of the non-alcoholic fatty liver disease (NAFLD), a major public health challenge. Nevertheless, NAFLD detection and diagnosis remain a difficult task. Fatty acid binding protein 4 (FABP4) has been proposed as potential biomarker for the ectopic fat accumulation in non-adipose tissues, although its role reflecting liver steatosis in metabolic patients is not fully explored. The aim of this study was to assess the relationship between FABP4 and the fatty liver index (FLI) in metabolic patients and to evaluate its potential role in the fatty liver disease. Methods: A cross-sectional study involving 389 participants at increased cardiometabolic risk was performed. FLI was calculated in order to assess liver fatty disease and a FLI ? 60 was considered to define liver steatosis. The serum FABP4 levels were assessed by using a sandwich enzyme-linked immunosorbent assay. Multivariable regression models were used to examine the associations of FABP4 with fatty liver after adjusting for demographic and clinical characteristics. Results: Both, FLI and serum FABP4 levels were upregulated in diabetic, obese, and metabolic syndrome patients. Serum FABP4 levels were higher in individuals with liver steatosis. Serum FABP4 were robustly associated with FLI in metabolic patients in both linear and logistic regression analyses. Conclusion: Our findings show that the serum FABP4 is associated to liver steatosis in metabolic patients. Copyright © 2021 Rodríguez-Calvo, Moreno-Vedia, Girona, Ibarretxe, Martínez-Micaelo, Merino, Plana and Masana.
  • Otros:

    Autor según el artículo: Rodríguez-Calvo R; Moreno-Vedia J; Girona J; Ibarretxe D; Martínez-Micaelo N; Merino J; Plana N; Masana L
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis / MERINO RIBAS, JORDI / Moreno Vedia, Juan / Plana Gil, Núria / Rodríguez Calvo, Ricardo
    Palabras clave: Nafld (non-alcoholic fatty liver disease) Metabolic patients Fli (fatty liver index) Fatty liver Fabp4 (fatty acid binding protein 4) External validation nafld (non-alcoholic fatty liver disease) metabolic patients indicator index fli (fatty liver index) fatty liver etiology disease cohort
    Resumen: Background: Liver steatosis is considered the onset of the non-alcoholic fatty liver disease (NAFLD), a major public health challenge. Nevertheless, NAFLD detection and diagnosis remain a difficult task. Fatty acid binding protein 4 (FABP4) has been proposed as potential biomarker for the ectopic fat accumulation in non-adipose tissues, although its role reflecting liver steatosis in metabolic patients is not fully explored. The aim of this study was to assess the relationship between FABP4 and the fatty liver index (FLI) in metabolic patients and to evaluate its potential role in the fatty liver disease. Methods: A cross-sectional study involving 389 participants at increased cardiometabolic risk was performed. FLI was calculated in order to assess liver fatty disease and a FLI ? 60 was considered to define liver steatosis. The serum FABP4 levels were assessed by using a sandwich enzyme-linked immunosorbent assay. Multivariable regression models were used to examine the associations of FABP4 with fatty liver after adjusting for demographic and clinical characteristics. Results: Both, FLI and serum FABP4 levels were upregulated in diabetic, obese, and metabolic syndrome patients. Serum FABP4 levels were higher in individuals with liver steatosis. Serum FABP4 were robustly associated with FLI in metabolic patients in both linear and logistic regression analyses. Conclusion: Our findings show that the serum FABP4 is associated to liver steatosis in metabolic patients. Copyright © 2021 Rodríguez-Calvo, Moreno-Vedia, Girona, Ibarretxe, Martínez-Micaelo, Merino, Plana and Masana.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: daiana.ibarretxe@urv.cat neus.martinez@urv.cat luis.masana@urv.cat josefa.girona@urv.cat ricardo.rodriguez@urv.cat josefa.girona@urv.cat juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
    Identificador del autor: 0000-0002-0789-4954 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-2673-3822 0000-0002-2673-3822
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fphys.2021.781789/full?utm_source=dlvr.it&utm_medium=twitter
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Frontiers In Physiology. 12
    Referencia de l'ítem segons les normes APA: Rodríguez-Calvo R; Moreno-Vedia J; Girona J; Ibarretxe D; Martínez-Micaelo N; Merino J; Plana N; Masana L (2021). Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk. Frontiers In Physiology, 12(), -. DOI: 10.3389/fphys.2021.781789
    DOI del artículo: 10.3389/fphys.2021.781789
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Physiology,Physiology (Medical)
    Nafld (non-alcoholic fatty liver disease)
    Metabolic patients
    Fli (fatty liver index)
    Fatty liver
    Fabp4 (fatty acid binding protein 4)
    External validation
    nafld (non-alcoholic fatty liver disease)
    metabolic patients
    indicator
    index
    fli (fatty liver index)
    fatty liver
    etiology
    disease
    cohort
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Physiology (medical)
    Physiology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias iv
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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