Articles producció científica> Química Física i Inorgànica

Enantioselective Pd-Catalyzed Allylic Substitution using Phosphite-Oxazoline PHOX-Based Ligands containing a Methylene Linker

  • Datos identificativos

    Identificador: imarina:9247851
    Autores:
    de la Cruz-Sanchez, PolBiosca, MariaMagre, MarcFaiges, JorgeMargalef, JessicaPamies, OscarDieguez, Montserrat
    Resumen:
    High enantioselectivities (up to 99 %) and activities (TOF's up to >4000 h(-1)) are accomplished in the Pd-catalyzed allylic substitution of a wide range of substrate types and nucleophiles using a family of phosphite-oxazoline ligands. These ligands were derived from the PHOX ligand by exchanging the phosphine moieties by biaryl phosphites and a methylene spacer was introduced between the oxazoline and the phenyl ring. The wide substrate scope is due to the ability of the ligand family to adapt their ligand parameters to the reacting substrate. This ability also explains its high performance in other type of catalytic processes.
  • Otros:

    Autor según el artículo: de la Cruz-Sanchez, Pol; Biosca, Maria; Magre, Marc; Faiges, Jorge; Margalef, Jessica; Pamies, Oscar; Dieguez, Montserrat;
    Departamento: Química Física i Inorgànica
    Autor/es de la URV: Biosca Brull, Maria / De La Cruz Sánchez Badia, Pol / Diéguez Fernández, Montserrat / Faiges Marcos, Jorge / Margalef Pallarès, Jèssica / Pamies Ollé, Oscar
    Palabras clave: Thioether ligands Palladium P,n-ligands P N-ligands Molecular-orbital methods Mechanistic investigation Force-field parameters Design Complexes Basis-set Asymmetric-synthesis Asymmetric catalysis Allylic substitution Allylation Alkylation Ab-initio
    Resumen: High enantioselectivities (up to 99 %) and activities (TOF's up to >4000 h(-1)) are accomplished in the Pd-catalyzed allylic substitution of a wide range of substrate types and nucleophiles using a family of phosphite-oxazoline ligands. These ligands were derived from the PHOX ligand by exchanging the phosphine moieties by biaryl phosphites and a methylene spacer was introduced between the oxazoline and the phenyl ring. The wide substrate scope is due to the ability of the ligand family to adapt their ligand parameters to the reacting substrate. This ability also explains its high performance in other type of catalytic processes.
    Áreas temáticas: Química Medicina i Materiais Interdisciplinar Inorganic chemistry Farmacia Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Chemistry, inorganic & nuclear Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: maria.biosca@urv.cat pol.delacruzsanchez@estudiants.urv.cat pol.delacruzsanchez@estudiants.urv.cat jorge.faiges@urv.cat oscar.pamies@urv.cat montserrat.dieguez@urv.cat
    Identificador del autor: 0000-0002-9116-6318 0000-0002-2352-8508 0000-0002-8450-0656
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.202100988
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: European Journal Of Inorganic Chemistry. 2022 (10):
    Referencia de l'ítem segons les normes APA: de la Cruz-Sanchez, Pol; Biosca, Maria; Magre, Marc; Faiges, Jorge; Margalef, Jessica; Pamies, Oscar; Dieguez, Montserrat; (2022). Enantioselective Pd-Catalyzed Allylic Substitution using Phosphite-Oxazoline PHOX-Based Ligands containing a Methylene Linker. European Journal Of Inorganic Chemistry, 2022(10), -. DOI: 10.1002/ejic.202100988
    DOI del artículo: 10.1002/ejic.202100988
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry, Inorganic & Nuclear,Inorganic Chemistry
    Thioether ligands
    Palladium
    P,n-ligands
    P
    N-ligands
    Molecular-orbital methods
    Mechanistic investigation
    Force-field parameters
    Design
    Complexes
    Basis-set
    Asymmetric-synthesis
    Asymmetric catalysis
    Allylic substitution
    Allylation
    Alkylation
    Ab-initio
    Química
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Chemistry, inorganic & nuclear
    Astronomia / física
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