Articles producció científica> Medicina i Cirurgia

Effectiveness of sequential intravenous-to-oral antibiotic switch therapy in hospitalized patients with gram-positive infection: the SEQUENCE cohort study

  • Datos identificativos

    Identificador: imarina:9267389
    Autores:
    Rodriguez-Pardo, D.Pigrau, C.Campany, D.Diaz-Brito, V.Morata, L.de Diego, I. C.Sorli, L.Iftimie, S.Perez-Vidal, R.Garcia-Pardo, G.Larrainzar-Coghen, T.Almirante, B.
    Resumen:
    Switching from intravenous to oral antibiotic therapy may improve inpatient management and reduce hospital stays and the complications of intravenous treatment. We aimed to assess the effectiveness of intravenous-to-oral antibiotic switch therapy and an early discharge algorithm in hospitalized patients with gram-positive infection. We performed a prospective cohort study with a retrospective comparison cohort, recruited from eight tertiary, acute-care Spanish referral hospitals. All patients included had culture-confirmed methicillin-resistant gram-positive infection, or methicillin-susceptible gram-positive infection and beta-lactam allergy and had received intravenous treatment with glycopeptides, lipopeptides, or linezolid. The study comprised two cohorts: the prospective cohort to assess the effectiveness of a sequential intravenous-to-oral antibiotic switch algorithm and early discharge, and a retrospective cohort in which the algorithm had not been applied, used as the comparator. A total of 247 evaluable patients were included; 115 in the prospective and 132 in the retrospective cohort. Forty-five retrospective patients (34 %) were not changed to oral antibiotics, and 87 (66 %) were changed to oral antibiotics without following the proposed algorithm. The duration of hospitalization was significantly shorter in the prospective cohort compared to the retrospective group that did not switch to oral drugs (16.7 +/- 18.7 vs 23 +/- 13.4 days, P < 0.001). No differences were observed regarding the incidence of catheter-related bacteraemia (4.4 % vs 2.6 %, P = 0.621). Our results suggest that an intravenous-to-oral antibiotic switch strategy is effective for reducing the length of hospital stay in selected hospitalized patients with gram-positive infection.
  • Otros:

    Autor según el artículo: Rodriguez-Pardo, D.; Pigrau, C.; Campany, D.; Diaz-Brito, V.; Morata, L.; de Diego, I. C.; Sorli, L.; Iftimie, S.; Perez-Vidal, R.; Garcia-Pardo, G.; Larrainzar-Coghen, T.; Almirante, B.;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Garcia Pardo, Graciano / Iftimie Iftimie, Simona Mihaela
    Palabras clave: Stewardship Resistant staphylococcus-aureus Iv Implementation Impact Guidelines Early discharge Complicated skin
    Resumen: Switching from intravenous to oral antibiotic therapy may improve inpatient management and reduce hospital stays and the complications of intravenous treatment. We aimed to assess the effectiveness of intravenous-to-oral antibiotic switch therapy and an early discharge algorithm in hospitalized patients with gram-positive infection. We performed a prospective cohort study with a retrospective comparison cohort, recruited from eight tertiary, acute-care Spanish referral hospitals. All patients included had culture-confirmed methicillin-resistant gram-positive infection, or methicillin-susceptible gram-positive infection and beta-lactam allergy and had received intravenous treatment with glycopeptides, lipopeptides, or linezolid. The study comprised two cohorts: the prospective cohort to assess the effectiveness of a sequential intravenous-to-oral antibiotic switch algorithm and early discharge, and a retrospective cohort in which the algorithm had not been applied, used as the comparator. A total of 247 evaluable patients were included; 115 in the prospective and 132 in the retrospective cohort. Forty-five retrospective patients (34 %) were not changed to oral antibiotics, and 87 (66 %) were changed to oral antibiotics without following the proposed algorithm. The duration of hospitalization was significantly shorter in the prospective cohort compared to the retrospective group that did not switch to oral drugs (16.7 +/- 18.7 vs 23 +/- 13.4 days, P < 0.001). No differences were observed regarding the incidence of catheter-related bacteraemia (4.4 % vs 2.6 %, P = 0.621). Our results suggest that an intravenous-to-oral antibiotic switch strategy is effective for reducing the length of hospital stay in selected hospitalized patients with gram-positive infection.
    Áreas temáticas: Saúde coletiva Odontología Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: graciano.garcia@urv.cat simonamihaela.iftime@urv.cat
    Identificador del autor: 0000-0003-0714-8414
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s10096-016-2661-5
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: European Journal Of Clinical Microbiology & Infectious Diseases. 35 (8): 1269-1276
    Referencia de l'ítem segons les normes APA: Rodriguez-Pardo, D.; Pigrau, C.; Campany, D.; Diaz-Brito, V.; Morata, L.; de Diego, I. C.; Sorli, L.; Iftimie, S.; Perez-Vidal, R.; Garcia-Pardo, G.; (2016). Effectiveness of sequential intravenous-to-oral antibiotic switch therapy in hospitalized patients with gram-positive infection: the SEQUENCE cohort study. European Journal Of Clinical Microbiology & Infectious Diseases, 35(8), 1269-1276. DOI: 10.1007/s10096-016-2661-5
    DOI del artículo: 10.1007/s10096-016-2661-5
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    Stewardship
    Resistant staphylococcus-aureus
    Iv
    Implementation
    Impact
    Guidelines
    Early discharge
    Complicated skin
    Saúde coletiva
    Odontología
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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