Repositori URV

Autor según el artículo: Cobo-López, Sergio; Gupta, Vinod K; Sung, Jaeyun; Guimerà, Roger; Sales-Pardo, Marta

Departamento: Enginyeria Química

Autor/es de la URV: Cobo Lopez, Sergio / Guimera Manrique, Roger / Sales Pardo, Marta

Resumen: Abstract A key question in human gut microbiome research is what are the robust structural patterns underlying its taxonomic composition. Herein, we use whole metagenomic datasets from healthy human guts to show that such robust patterns do exist, albeit not in the conventional enterotype sense. We first introduce the concept of mixed-membership enterotypes using a network inference approach based on stochastic block models. We find that gut microbiomes across a group of people (hosts) display a nested structure, which has been observed in a number of ecological systems. This finding led us to designate distinct ecological roles to both microbes and hosts: generalists and specialists. Specifically, generalist hosts have microbiomes with most microbial species, while specialist hosts only have generalist microbes. Moreover, specialist microbes are only present in generalist hosts. From the nested structure of microbial taxonomies, we show that these ecological roles of microbes are generally conserved across datasets. Our results show that the taxonomic composition of healthy human gut microbiomes is associated with robustly structured combinations of generalist and specialist species.

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: sergio.cobo@urv.cat roger.guimera@urv.cat marta.sales@urv.cat

Identificador del autor: 0000-0002-3597-4310 0000-0002-8140-6525

Fecha de alta del registro: 2023-11-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://academic.oup.com/pnasnexus/article/1/3/pgac055/6590842

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Pnas Nexus. 1 (3):

Referencia de l'ítem segons les normes APA: Cobo-López, Sergio; Gupta, Vinod K; Sung, Jaeyun; Guimerà, Roger; Sales-Pardo, Marta (2022). Stochastic block models reveal a robust nested pattern in healthy human gut microbiomes. Pnas Nexus, 1(3), -. DOI: 10.1093/pnasnexus/pgac055

DOI del artículo: 10.1093/pnasnexus/pgac055

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2022

Tipo de publicación: Journal Publications