Autor según el artículo: Antequera-González, B; Faiges, M; Martínez-Micaelo, N; Galian-Gay, L; Ligero, C; Ferré-Vallverdú, M; Masana, L; Amigó, N; Evangelista, A; Alegret, JM
Departamento: Medicina i Cirurgia
Autor/es de la URV: Alegret Colomé, Josep Maria / Antequera González, Borja / Faiges Borràs, Marta Jesús / Ferré Vallverdú, Maria / Ligero Ferrer, Maria Carmen / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis
Palabras clave: Remnant cholesterol Magnetic-resonance Lipoprotein metabolism Hmr Glycoprotein Bicuspid aortic valve Bav Ascending aortic dilatation triglycerides risk-factors remnant cholesterol oxidative stress lipoprotein metabolism lipids ldl cholesterol hmr glycoprotein bav ascending aortic dilatation apolipoprotein-b aneurysm
Resumen: Introduction: The bicuspid aortic valve (BAV) confers a high risk of ascending aorta dilatation (AAoD), although its progression seems highly variable. Furthermore, the implication of lipoprotein metabolism and inflammation in the mechanisms that underlie AAoD is not fully established. The aim of this study consisted of evaluating the impact of the lipoprotein and glycoprotein profiles in AAOD as well as its progression in BAV aortopathy. Methods: Using 1H-nuclear magnetic resonance (1H-NMR), we analyzed and compared the lipoprotein and glycoprotein profiles of plasma samples from 152 BAV patients with dilated and nondilated ascending aorta. Additionally, these profiles were also compared for 119 of these patients who were prospectively followed-up clinically and by echocardiography in the long-term (5 years). Ascending aorta dilation velocity (mm/year) was calculated for this analysis. Results: Several parameters related to the lipoprotein profile including remnant cholesterol, small LDL and IDL-cholesterol were found to be significantly increased in the dilated group compared to those in the nondilated group. The glycoprotein A-nuclear magnetic resonance (NMR) signal, a novel inflammation biomarker, was also observed to be increased in the dilated group. After performing multivariate analysis, remnant cholesterol remained an independent variable related to AAoD. In the long-term follow-up, proatherogenic lipoprotein parameters were related to ascending aorta dilatation velocity ascending. After a lineal regression analysis, non-HDL particles remained as an independent predictor of ascending aorta dilation velocity. Conclusions: Patients with BAV and AAoD presented a more pro-atherogenic profile assessed by 1H-NMR, especially related to triglyceride-rich lipoproteins. This pro-atherogenic profile seems to contribute to the higher growth rate of ascending aorta diameter.
Áreas temáticas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: neus.martinez@urv.cat luis.masana@urv.cat maria.ferrev@urv.cat mariacarmen.ligero@urv.cat marta.faiges@estudiants.urv.cat borja.antequera@estudiants.urv.cat borja.antequera@estudiants.urv.cat mariacarmen.ligero@urv.cat josepmaria.alegret@urv.cat
Identificador del autor: 0000-0002-0789-4954 0000-0002-6117-5512
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Clinical Medicine. 12 (1):
Referencia de l'ítem segons les normes APA: Antequera-González, B; Faiges, M; Martínez-Micaelo, N; Galian-Gay, L; Ligero, C; Ferré-Vallverdú, M; Masana, L; Amigó, N; Evangelista, A; Alegret, JM (2023). Glycoprotein and Lipoprotein Profiles Assessed by 1H-NMR and Its Relation to Ascending Aortic Dilatation in Bicuspid Aortic Valve Disease. Journal Of Clinical Medicine, 12(1), -. DOI: 10.3390/jcm12010332
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV