Articles producció científica> Medicina i Cirurgia

Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013

  • Datos identificativos

    Identificador: imarina:9296786
    Autores:
    Berenguer, JuanBohlius, JuliaBouteloup, VincentBucher, HeinerCozzi-Lepri, AlessandroDabis, FrancoisMonforte, Antonella d'ArminioDavies, Mary-Annedel Amo, JuliaDorrucci, MariaDunn, DavidEgger, MatthiasFurrer, HansjakobGuiguet, MargueriteGrabar, SophieJudd, AliKirk, OleLambotte, OlivierLeroy, ValerianeLodi, SaraMatheron, SophieMeyer, LaurenceMiro, Jose M.Mocroft, AmandaMonge, SusanaNakagawa, FumiyoParedes, RogerPhillips, AndrewPuoti, MassimoSchomaker, MichaelSmit, ColetteSterne, JonathanThiebaut, RodolpheThorne, ClaireTorti, Carlovan der Valk, MarcWittkop, LindaWyss, NatashaLate Presenters Working Grp COHERE
    Resumen:
    Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010-2013. People aged >= 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrolment) after 1 January 2010 with available CD4 count within six months of presentation were included. LP was defined as presentation with a CD4 count < 350/mm(3) or an AIDS defining event (at any CD4), in the six months following HIV diagnosis. Logistic regression investigated changes in LP over time. A total of 30,454 people were included. The median CD4 count at presentation was 368/mm(3) (interquartile range (IQR) 193-555/mm(3)), with no change over time (p = 0.70). In 2010, 4,775/10,766 (47.5%) were LP whereas in 2013, 1,642/3,375 (48.7%) were LP (p = 0.63). LP was most common in central Europe (4,791/9,625, 49.8%), followed by northern (5,704/11,692; 48.8%), southern (3,550/7,760; 45.8%) and eastern Europe (541/1,377; 38.3%; p < 0.0001). There was a significant increase in LP in male and female people who inject drugs (PWID) (adjusted odds ratio (aOR)/year later 1.16; 95% confidence interval (CI): 1.02-1.32), and a significant decline in LP in northern Europe (aOR/year later 0.89; 95% CI: 0.85-0.94). Further improvements in effective HIV testing strategies, with a focus on vulnerable groups, are required across the European continent.
  • Otros:

    Autor según el artículo: Berenguer, Juan; Bohlius, Julia; Bouteloup, Vincent; Bucher, Heiner; Cozzi-Lepri, Alessandro; Dabis, Francois; Monforte, Antonella d'Arminio; Davies, Mary-Anne; del Amo, Julia; Dorrucci, Maria; Dunn, David; Egger, Matthias; Furrer, Hansjakob; Guiguet, Marguerite; Grabar, Sophie; Judd, Ali; Kirk, Ole; Lambotte, Olivier; Leroy, Valeriane; Lodi, Sara; Matheron, Sophie; Meyer, Laurence; Miro, Jose M.; Mocroft, Amanda; Monge, Susana; Nakagawa, Fumiyo; Paredes, Roger; Phillips, Andrew; Puoti, Massimo; Schomaker, Michael; Smit, Colette; Sterne, Jonathan; Thiebaut, Rodolphe; Thorne, Claire; Torti, Carlo; van der Valk, Marc; Wittkop, Linda; Wyss, Natasha;Late Presenters Working Grp COHERE
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Vidal Marsal, Francisco
    Palabras clave: Trends People Late presentation Infection Human immunodeficiency virus - hiv Health Era Epidemiology Count Consensus definition Combination antiretroviral therapy Cohort Burden
    Resumen: Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010-2013. People aged >= 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrolment) after 1 January 2010 with available CD4 count within six months of presentation were included. LP was defined as presentation with a CD4 count < 350/mm(3) or an AIDS defining event (at any CD4), in the six months following HIV diagnosis. Logistic regression investigated changes in LP over time. A total of 30,454 people were included. The median CD4 count at presentation was 368/mm(3) (interquartile range (IQR) 193-555/mm(3)), with no change over time (p = 0.70). In 2010, 4,775/10,766 (47.5%) were LP whereas in 2013, 1,642/3,375 (48.7%) were LP (p = 0.63). LP was most common in central Europe (4,791/9,625, 49.8%), followed by northern (5,704/11,692; 48.8%), southern (3,550/7,760; 45.8%) and eastern Europe (541/1,377; 38.3%; p < 0.0001). There was a significant increase in LP in male and female people who inject drugs (PWID) (adjusted odds ratio (aOR)/year later 1.16; 95% confidence interval (CI): 1.02-1.32), and a significant decline in LP in northern Europe (aOR/year later 0.89; 95% CI: 0.85-0.94). Further improvements in effective HIV testing strategies, with a focus on vulnerable groups, are required across the European continent.
    Áreas temáticas: Virology Saúde coletiva Public health, environmental and occupational health Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Infectious diseases General medicine Farmacia Epidemiology Ciências biológicas iii Ciências agrárias i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: francesc.vidal@urv.cat
    Identificador del autor: 0000-0002-6692-6186
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2015.20.47.30070
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Eurosurveillance. 20 (47): 7-18
    Referencia de l'ítem segons les normes APA: Berenguer, Juan; Bohlius, Julia; Bouteloup, Vincent; Bucher, Heiner; Cozzi-Lepri, Alessandro; Dabis, Francois; Monforte, Antonella d'Arminio; Davies, (2015). Late presentation for HIV care across Europe: update from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study, 2010 to 2013. Eurosurveillance, 20(47), 7-18. DOI: 10.2807/1560-7917.ES.2015.20.47.30070
    DOI del artículo: 10.2807/1560-7917.ES.2015.20.47.30070
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2015
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Epidemiology,Infectious Diseases,Medicine (Miscellaneous),Public Health, Environmental and Occupational Health,Virology
    Trends
    People
    Late presentation
    Infection
    Human immunodeficiency virus - hiv
    Health
    Era
    Epidemiology
    Count
    Consensus definition
    Combination antiretroviral therapy
    Cohort
    Burden
    Virology
    Saúde coletiva
    Public health, environmental and occupational health
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Infectious diseases
    General medicine
    Farmacia
    Epidemiology
    Ciências biológicas iii
    Ciências agrárias i
    Biotecnología
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