Autor según el artículo: Pah, A R; Guimera, R; Mustoe, A M; Amaral, L A N
Departamento: Enginyeria Química
Autor/es de la URV: Guimera Manrique, Roger
Palabras clave: User-computer interface Transportation network Signal transduction Reconstruction Motifs Models, biological Metabolome Kegg Information storage and retrieval Humans Genomics Genes Generation Evolution Databases, genetic Computer simulation Cartography Biochemical networks Annotation Animals
Resumen: The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts. Here, we tackle the challenge of curating metabolic network reconstructions. We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. While sequence homology has been a standard to annotate metabolic networks it has been faulted for its lack of predictive power. We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. Additionally, we compare the annotation behavior of current database curation efforts with our predictions and find that curation efforts are biased towards adding (rather than removing) reactions to organismal networks.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: roger.guimera@urv.cat
Identificador del autor: 0000-0002-3597-4310
Fecha de alta del registro: 2024-10-26
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/srep01695
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Scientific Reports. 3 1695-
Referencia de l'ítem segons les normes APA: Pah, A R; Guimera, R; Mustoe, A M; Amaral, L A N (2013). Use of a global metabolic network to curate organismal metabolic networks. Scientific Reports, 3(), 1695-. DOI: 10.1038/srep01695
DOI del artículo: 10.1038/srep01695
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2013
Tipo de publicación: Journal Publications