Articles producció científica> Enginyeria Química

Use of a global metabolic network to curate organismal metabolic networks

  • Datos identificativos

    Identificador: imarina:9298212
    Autores:
    Pah, A RGuimera, RMustoe, A MAmaral, L A N
    Resumen:
    The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts. Here, we tackle the challenge of curating metabolic network reconstructions. We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. While sequence homology has been a standard to annotate metabolic networks it has been faulted for its lack of predictive power. We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. Additionally, we compare the annotation behavior of current database curation efforts with our predictions and find that curation efforts are biased towards adding (rather than removing) reactions to organismal networks.
  • Otros:

    Autor según el artículo: Pah, A R; Guimera, R; Mustoe, A M; Amaral, L A N
    Departamento: Enginyeria Química
    Autor/es de la URV: Guimera Manrique, Roger
    Palabras clave: User-computer interface Transportation network Signal transduction Reconstruction Motifs Models, biological Metabolome Kegg Information storage and retrieval Humans Genomics Genes Generation Evolution Databases, genetic Computer simulation Cartography Biochemical networks Annotation Animals
    Resumen: The difficulty in annotating the vast amounts of biological information poses one of the greatest current challenges in biological research. The number of genomic, proteomic, and metabolomic datasets has increased dramatically over the last two decades, far outstripping the pace of curation efforts. Here, we tackle the challenge of curating metabolic network reconstructions. We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. While sequence homology has been a standard to annotate metabolic networks it has been faulted for its lack of predictive power. We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. Additionally, we compare the annotation behavior of current database curation efforts with our predictions and find that curation efforts are biased towards adding (rather than removing) reactions to organismal networks.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: roger.guimera@urv.cat
    Identificador del autor: 0000-0002-3597-4310
    Fecha de alta del registro: 2024-10-26
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nature.com/articles/srep01695
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Scientific Reports. 3 1695-
    Referencia de l'ítem segons les normes APA: Pah, A R; Guimera, R; Mustoe, A M; Amaral, L A N (2013). Use of a global metabolic network to curate organismal metabolic networks. Scientific Reports, 3(), 1695-. DOI: 10.1038/srep01695
    DOI del artículo: 10.1038/srep01695
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2013
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Multidisciplinary,Multidisciplinary Sciences
    User-computer interface
    Transportation network
    Signal transduction
    Reconstruction
    Motifs
    Models, biological
    Metabolome
    Kegg
    Information storage and retrieval
    Humans
    Genomics
    Genes
    Generation
    Evolution
    Databases, genetic
    Computer simulation
    Cartography
    Biochemical networks
    Annotation
    Animals
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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