Autor según el artículo: Isabel Queipo-Ortuno, Maria; Escote, Xavier; Ceperuelo-Mallafre, Victoria; Garrido-Sanchez, Lourdes; Miranda, Merce; Clemente-Postigo, Mercedes; Perez-Perez, Rafael; Peral, Belen; Cardona, Fernando; Manuel Fernandez-Real, Jose; Tinahones, Francisco J.; Vendrell, Joan;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria / Escote Miro, Xavier / MIRANDA GUARDIOLA, MERCEDES / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
Palabras clave: Women Type-2 diabetic-patients Metabolic-syndrome Insulin-resistance Fatty-acid-binding-protein-4 Disease Biomarker Atherosclerosis Ap2 Acid-binding protein
Resumen: Background: FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile.Objective: In patients with a wide BMI range, we analyze FABP4 expression in adipose and hepatic tissues in the settings of obesity and insulin resistance. Associations between FABP4 expression in adipose tissue and the FABP4 plasma level as well as the main adipogenic and lipolytic genes expressed in adipose tissue were also analyzed.Methods: The expression of several lipogenic, lipolytic, PPAR family and FABP family genes was analyzed by real time PCR. FABP4 protein expression in total adipose tissues and its fractions were determined by western blot. Results: In obesity FABP4 expression was down-regulated (at both mRNA and protein levels), with its levels mainly predicted by ATGL and inversely by the HOMA-IR index. The BMI appeared as the only determinant of the FABP4 variation in both adipose tissue depots. FABP4 plasma levels showed a significant progressive increase according to BMI but no association was detected between FABP4 circulating levels and SAT or VAT FABP4 gene expression. The gene expression of FABP1, FABP4 and FABP5 in hepatic tissue was significantly higher in tissue from the obese IRpatients compared to the non-IR group.Conclusion: The inverse pattern in FABP4 expression between adipose and hepatic tissue observed in morbid obese patients, regarding the IR context, suggests that both tissues may act in a balanced manner. These differences may help us to understand the discrepancies between circulating plasma levels and adipose tissue expression in obesity.
Áreas temáticas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat
Identificador del autor: 0000-0002-4460-9761 0000-0002-6994-6115
Fecha de alta del registro: 2024-01-14
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048605
Referencia al articulo segun fuente origial: Plos One. 7 (11):
Referencia de l'ítem segons les normes APA: Isabel Queipo-Ortuno, Maria; Escote, Xavier; Ceperuelo-Mallafre, Victoria; Garrido-Sanchez, Lourdes; Miranda, Merce; Clemente-Postigo, Mercedes; Perez (2012). FABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels. Plos One, 7(11), -. DOI: 10.1371/journal.pone.0048605
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1371/journal.pone.0048605
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2012
Tipo de publicación: Journal Publications
Repositori URV