Autor según el artículo: Gómez-Pérez, AM; Ruiz-Limón, P; Salas-Salvadó, J; Vioque, J; Corella, D; Fitó, M; Vidal, J; Atzeni, A; Torres-Collado, L; Alvarez-Sala, A; Martínez, MA; Goday, A; Benaiges, D; García-Gavilán, J; López, MRB; Moreno-Indias, I; Tinahones, FJ
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Atzeni, Alessandro / García Gavilán, Jesús Francisco / Martínez Rodríguez, María Ángeles / Salas Salvadó, Jorge
Palabras clave: The fibrosis-4 score Non-alcoholic fatty liver disease Microbiome Metabolic syndrome Metabolic liver disease Mediterranean diet Liver Humans Hepatic steatosis index Gastrointestinal microbiome Gastric bypass Fibrosis the fibrosis-4 score metabolic liver disease mediterranean diet intervention hepatic steatosis index acid
Resumen: To evaluate the changes in the gut microbiota associated with changes in the biochemical markers of nonalcoholic fatty liver disease (NAFLD) after a lifestyle intervention with the Mediterranean diet. Participants (n = 297) from two centers of PREDIMED-Plus trial (Prevención con Dieta Mediterránea) were divided into three different groups based on the change tertile in the Hepatic Steatosis Index (HSI) or the Fibrosis-4 score (FIB-4) between baseline and one year of intervention. One-year changes in HSI were: tertile 1 (T1) (-24.9 to -7.51), T2 (-7.5 to -1.86), T3 (-1.85 to 13.64). The most significant differences in gut microbiota within the year of intervention were observed in the T1 and T3. According to the FIB-4, participants were categorized in non-suspected fibrosis (NSF) and with indeterminate or suspected fibrosis (SF). NSF participants showed higher abundances of Alcaligenaceae, Bacteroidaceae, Bifidobacteriaceae, Clostridiaceae, Enterobacteriaceae, Peptostreptococcaceae, Verrucomicrobiaceae compared to those with SF. Then, participants were divided depending on the FIB-4 tertile of change: T1 (-89.60 to -5.57), T2 (-5.56 to 11.4), and T3 (11.41 to 206.24). FIB-4 T1 showed a decrease in Akkermansia and an increase in Desulfovibrio. T2 had an increase in Victivallaceae, Clostridiaceae, and Desulfovibrio. T3 showed a decrease in Enterobacteriaceae, and an increase in Sutterella, Faecalibacterium, and Blautia. A relation between biochemical index changes of NAFLD/NASH (HSI and FIB-4) and gut microbiota changes were found. These observations highlight the importance of lifestyle intervention in the modulation of gut microbiota and the management of metabolic syndrome and its hepatic manifestations.
Áreas temáticas: Microbiology (medical) Microbiology Medicina veterinaria Medicina i Infectious diseases Gastroenterology & hepatology Gastroenterology Ciências biológicas iii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat mangeles.martinez@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-1804-8606 0000-0001-8595-3772 0000-0002-1804-8606 0000-0003-2700-7459
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2223339
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Gut Microbes. 15 (1): 2223339-
Referencia de l'ítem segons les normes APA: Gómez-Pérez, AM; Ruiz-Limón, P; Salas-Salvadó, J; Vioque, J; Corella, D; Fitó, M; Vidal, J; Atzeni, A; Torres-Collado, L; Alvarez-Sala, A; Martínez, M (2023). Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis. Gut Microbes, 15(1), 2223339-. DOI: 10.1080/19490976.2023.2223339
DOI del artículo: 10.1080/19490976.2023.2223339
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV