Autor según el artículo: Biosca, M; Tarr, D; Pàmies, O; Diéguez, M
Departamento: Química Física i Inorgànica
Autor/es de la URV: Biosca Brull, Maria / Diéguez Fernández, Montserrat / Pamies Ollé, Oscar / Tarr González, Daniel James
Código de proyecto: Grant agreement No. 945413
Palabras clave: Pauson-khand reaction Palladium P,n-ligands Kinetic resolution Cyclization Asymmetric allylic substitution sesquiterpene pauson-khand reaction palladium p n-ligands functionalization esters cyclization catalysis carbonates asymmetric induction alkylation alcohols
Resumen: Pd-catalyzed asymmetric allylic substitution (AAS) is a highly effective method for producing chiral molecules with alkene-substituted frameworks which can be further derivatized. However, its stereochemical outcome is affected by the steric requirements of the substrate and only a narrow set of nucleophiles yield excellent enantioselectivities. In this regard, phosphite-oxazolines have emerged as strong candidates to be privileged ligands for this process, providing results that surpass most of the previously published studies. They have provided high enantiocontrol when used in the Pd-AAS of several hindered and unhindered substrates, using a wide range of C-, O-, and N-nucleophiles. In this concept, we review and discuss the current progress made in the design of tailor-made phosphite-oxazoline ligand libraries for the Pd-AAS of a broad range of substrates and nucleophiles and its application in the construction of chiral complex molecules.
Áreas temáticas: Química Physical and theoretical chemistry Organic chemistry Materiais Interdisciplinar Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências agrárias i Ciência de alimentos Chemistry, organic Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: danieljames.tarr@urv.cat maria.biosca@urv.cat oscar.pamies@urv.cat montserrat.dieguez@urv.cat
Identificador del autor: 0000-0002-9116-6318 0000-0002-2352-8508 0000-0002-8450-0656
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300429
Programa de financiación: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: European Journal Of Organic Chemistry. 26 (36):
Referencia de l'ítem segons les normes APA: Biosca, M; Tarr, D; Pàmies, O; Diéguez, M (2023). The Evolution of Phosphite-Oxazoline Ligands for the Pd-Allylic Substitution and Their Application in Building Chiral Molecules. European Journal Of Organic Chemistry, 26(36), -. DOI: 10.1002/ejoc.202300429
Acrónimo: MFP-Plus
DOI del artículo: 10.1002/ejoc.202300429
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Acción del progama de financiación: Martí i Franquès COFUND Doctoral Programme
Tipo de publicación: Journal Publications
Repositori URV