Articles producció científica> Ciències Mèdiques Bàsiques

Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients

  • Datos identificativos

    Identificador: imarina:9326015
    Handle: https://hdl.handle.net/20.500.11797/imarina9326015
    Autores:
    Galli, FlaviaBindo, FrancescoMotos, AnnaFernandez-Barat, LaiaBarbeta, EnricGabarrus, AlbertCeccato, AdrianBermejo-Martin, Jesus FFerrer, RicardRiera, JordiPenuelas, OscarLorente, Jose Angelde Gonzalo-Calvo, DavidMenendez, RosarioGonzalez, JessicaMisuraca, SofiaPalomeque, AndreaAmaya-Villar, RosarioAnon, Jose ManuelBalan Marino, AnaBarbera, CarmeBarberan, JoseBlandino Ortiz, AaronBustamante-Munguira, ElenaCaballero, JesusCanton-Bulnes, Maria LuisaCarbajales Perez, CristinaCarbonell, NievesCatalan-Gonzalez, Mercedesde Frutos, RaulFranco, NievesGalban, CristobalLopez Lago, AnaGumucio-Sanguino, Victor Dde la Torre, Maria del CarmenDiaz, EmilioEstella, AngelGallego Curto, ElenaGarcia-Garmendia, Jose LuisGomez, Jose ManuelHuerta, ArturoJorge Garcia, Ruth NoemiLoza-Vazquez, AnaMarin-Corral, JudithMartin Delgado, Maria CruzMartinez de la Gandara, AmaliaMartinez Varela, IgnacioLopez Messa, JuanM Albaiceta, GuillermoNieto, Maria TeresaNovo, Mariana AndreaPenasco, YhivianPerez-Garcia, FelipePozo-Laderas, Juan CarlosRicart, PilarSagredo, VictorSanchez-Miralles, AngelSancho Chinesta, SusanaRoche-Campo, FerranSocias, LorenzoSole-Violan, JordiSuarez-Sipmann, FernandoTamayo Lomas, LuisTrenado, JoseUbeda, AlejandroValdivia, Luis JorgeVidal, PabloBoado, Maria VictoriaRodriguez, AlejandroAntonelli, MassimoBlasi, FrancescoBarbe, FerranTorres, Antoni
    Resumen:
    Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C-reactive protein (CRP) upon admission could be helpful biomarkers to identify bacterial coinfection among patients with COVID-19 pneumonia.We carried out a multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish intensive care units (ICUs). The primary outcome was to explore whether PCT or CRP serum levels upon hospital admission could predict bacterial coinfection among patients with COVID-19 pneumonia. The secondary outcome was the evaluation of their association with mortality. We also conducted subgroups analyses in higher risk profile populations.Between 5 February 2020 and 21 December 2021, 4076 patients were included, 133 (3%) of whom presented bacterial coinfection. PCT and CRP had low area under curve (AUC) scores at the receiver operating characteristic (ROC) curve analysis [0.57 (95% confidence interval (CI) 0.51-0.61) and 0.6 (95% CI, 0.55-0.64), respectively], but high negative predictive values (NPV) [97.5% (95% CI 96.5-98.5) and 98.2% (95% CI 97.5-98.9) for PCT and CRP, respectively]. CRP alone was associated with bacterial coinfection (OR 2, 95% CI 1.25-3.19; p = 0.004). The overall 15, 30 and 90 days mortality had a higher trend in the bacterial coinfection group, but without significant difference. PCT ≥ 0.12 ng/mL was associated with higher 90 days mortality.Our study suggests that measurements of PCT and CRP, alone and at a single time point, are not useful for ruling in or out bacterial coinfection in viral pne

  • Otros:

    Autor según el artículo: Galli, Flavia; Bindo, Francesco; Motos, Anna; Fernandez-Barat, Laia; Barbeta, Enric; Gabarrus, Albert; Ceccato, Adrian; Bermejo-Martin, Jesus F; Ferrer, Ricard; Riera, Jordi; Penuelas, Oscar; Lorente, Jose Angel; de Gonzalo-Calvo, David; Menendez, Rosario; Gonzalez, Jessica; Misuraca, Sofia; Palomeque, Andrea; Amaya-Villar, Rosario; Anon, Jose Manuel; Balan Marino, Ana; Barbera, Carme; Barberan, Jose; Blandino Ortiz, Aaron; Bustamante-Munguira, Elena; Caballero, Jesus; Canton-Bulnes, Maria Luisa; Carbajales Perez, Cristina; Carbonell, Nieves; Catalan-Gonzalez, Mercedes; de Frutos, Raul; Franco, Nieves; Galban, Cristobal; Lopez Lago, Ana; Gumucio-Sanguino, Victor D; de la Torre, Maria del Carmen; Diaz, Emilio; Estella, Angel; Gallego Curto, Elena; Garcia-Garmendia, Jose Luis; Gomez, Jose Manuel; Huerta, Arturo; Jorge Garcia, Ruth Noemi; Loza-Vazquez, Ana; Marin-Corral, Judith; Martin Delgado, Maria Cruz; Martinez de la Gandara, Amalia; Martinez Varela, Ignacio; Lopez Messa, Juan; M Albaiceta, Guillermo; Nieto, Maria Teresa; Novo, Mariana Andrea; Penasco, Yhivian; Perez-Garcia, Felipe; Pozo-Laderas, Juan Carlos; Ricart, Pilar; Sagredo, Victor; Sanchez-Miralles, Angel; Sancho Chinesta, Susana; Roche-Campo, Ferran; Socias, Lorenzo; Sole-Violan, Jordi; Suarez-Sipmann, Fernando; Tamayo Lomas, Luis; Trenado, Jose; Ubeda, Alejandro; Valdivia, Luis Jorge; Vidal, Pablo; Boado, Maria Victoria; Rodriguez, Alejandro; Antonelli, Massimo; Blasi, Francesco; Barbe, Ferran; Torres, Antoni
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Rodríguez Oviedo, Alejandro Hugo
    Palabras clave: Procalcitonin Intensive care Critically ill Covid-19 Community-acquired pneumonia C-reactive protein Bacterial coinfection statistics notes serum procalcitonin sepsis mortality intensive care infection etiology diagnosis decision critically ill covid-19 c-reactive protein bacterial coinfection adults
    Resumen: Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C-reactive protein (CRP) upon admission could be helpful biomarkers to identify bacterial coinfection among patients with COVID-19 pneumonia.We carried out a multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish intensive care units (ICUs). The primary outcome was to explore whether PCT or CRP serum levels upon hospital admission could predict bacterial coinfection among patients with COVID-19 pneumonia. The secondary outcome was the evaluation of their association with mortality. We also conducted subgroups analyses in higher risk profile populations.Between 5 February 2020 and 21 December 2021, 4076 patients were included, 133 (3%) of whom presented bacterial coinfection. PCT and CRP had low area under curve (AUC) scores at the receiver operating characteristic (ROC) curve analysis [0.57 (95% confidence interval (CI) 0.51-0.61) and 0.6 (95% CI, 0.55-0.64), respectively], but high negative predictive values (NPV) [97.5% (95% CI 96.5-98.5) and 98.2% (95% CI 97.5-98.9) for PCT and CRP, respectively]. CRP alone was associated with bacterial coinfection (OR 2, 95% CI 1.25-3.19; p = 0.004). The overall 15, 30 and 90 days mortality had a higher trend in the bacterial coinfection group, but without significant difference. PCT ≥ 0.12 ng/mL was associated with higher 90 days mortality.Our study suggests that measurements of PCT and CRP, alone and at a single time point, are not useful for ruling in or out bacterial coinfection in viral pneumonia by COVID-19.© 2023. The Author(s).
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Emergency medicine & critical care Educação física Critical care medicine Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: alejandrohugo.rodriguez@urv.cat
    Identificador del autor: 0000-0001-8828-5984
    Fecha de alta del registro: 2025-01-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Referencia al articulo segun fuente origial: Intensive Care Medicine. 49 (8): 934-945
    Referencia de l'ítem segons les normes APA: Galli, Flavia; Bindo, Francesco; Motos, Anna; Fernandez-Barat, Laia; Barbeta, Enric; Gabarrus, Albert; Ceccato, Adrian; Bermejo-Martin, Jesus F; Ferre (2023). Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients. Intensive Care Medicine, 49(8), 934-945. DOI: 10.1007/s00134-023-07161-1
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Critical Care and Intensive Care Medicine,Critical Care Medicine,Emergency Medicine & Critical Care
    Procalcitonin
    Intensive care
    Critically ill
    Covid-19
    Community-acquired pneumonia
    C-reactive protein
    Bacterial coinfection
    statistics notes
    serum procalcitonin
    sepsis
    mortality
    intensive care
    infection
    etiology
    diagnosis
    decision
    critically ill
    covid-19
    c-reactive protein
    bacterial coinfection
    adults
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Emergency medicine & critical care
    Educação física
    Critical care medicine
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i

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