C(sp2)-H Hydroxylation via Catalytic 1,4-Ni Migration with N2O

Identificador:  imarina:9326345

Handle: https://hdl.handle.net/20.500.11797/imarina9326345

Autores:  Zhang H; Rodrigalvarez J; Martin R

Resumen:
Herein, we report a Ni-catalyzed C(sp2)-H hydroxylation of aryl bromides with N2O as an oxygen-atom donor. The reaction is enabled by a 1,4-Ni translocation that results in ipso/ortho difunctionalized products. Regioselectivity and stereocontrol are dictated by a judicious choice of the ligand backbone, thus giving access to either carbonyl or phenol derivatives and offering an opportunity to repurpose hazardous substances en route to valuable oxygen-containing building blocks.