Autor según el artículo: Rius-Gordillo, N; Ferré, N; González, JD; Ibars, Z; Parada-Ricart, E; Escribano, J
Departamento: Medicina i Cirurgia
Autor/es de la URV: Escribano Subías, Joaquín / Ferre Pallas, Natalia / Parada Ricart, Esther / Rius Gordillo, Neus
Palabras clave: Urinary-tract-infections Kidney scarring Cytokines Corticosteroids Acute pyelonephritis vesicoureteral reflux serum risk renal scar kim-1 kidney scarring interleukin-8 cytokines corticosteroids children biomarkers
Resumen: Febrile urinary tract infection is a common bacterial infection in childhood. The kidney damage after acute pyelonephritis (APN) could be related to the stimulation of the proinflammatory response. We aimed to investigate the role of inflammatory cytokines and the effect of dexamethasone after a first episode of APN.Subanalysis of the DEXCAR RCT in which children with confirmed APN (1 month-14 years) were randomly assigned to receive a 3 days course of either intravenous dexamethasone or placebo. Urinary cytokine levels at diagnosis and after 72 h of treatment were measured.Ninety-two patients were recruited. Younger patients, males and those with abnormalities in the ultrasound study or vesicoureteral reflux showed higher values of urinary cytokines. Patients with severe APN had higher Tumour Necrosis Factor (TNF)α levels (81.0 ± 75.8 vs. 33.6 ± 48.5 pg/mg creatinine, p = 0.015). Both intervention groups showed similar basal clinical characteristics, including urinary cytokine levels. Treatment reduced urinary cytokine levels irrespective of dexamethasone administration. Neither the intervention group nor the urinary cytokine levels modulated the development of kidney scars.Basal urinary cytokines were associated with age, abnormal ultrasound and vesicoureteral reflux. Patients with severe APN had higher TNFa urinary levels. Administration of dexamethasone in children with APN does not improve the control of the proinflammatory cytokine cascade.© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
Áreas temáticas: Serviço social Saúde coletiva Psicología Pediatrics, perinatology and child health Pediatrics Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: neus.rius@urv.cat esther.parada@urv.cat joaquin.escribano@urv.cat natalia.ferre@urv.cat neus.rius@urv.cat
Identificador del autor: 0000-0002-5041-459X 0000-0002-2838-1525
Fecha de alta del registro: 2024-03-23
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1111/apa.17034
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Acta Paediatrica. 113 (3): 564-572
Referencia de l'ítem segons les normes APA: Rius-Gordillo, N; Ferré, N; González, JD; Ibars, Z; Parada-Ricart, E; Escribano, J (2024). Role of dexamethasone in controlling the proinflammatory cytokine cascade in the first episode of paediatric acute pyelonephritis. Acta Paediatrica, 113(3), 564-572. DOI: 10.1111/apa.17034
DOI del artículo: 10.1111/apa.17034
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV