Autor según el artículo: Cantons, Josep Maria; Bachhuka, Akash; Marsal, Lluis F
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/es de la URV: Bachhuka, Akash / Marsal Garví, Luis Francisco
Palabras clave: Aluminum oxide Angiogenic factors Biosensing Biosensing techniques Diagnosi Electrodes Endoglin Female Fluorescence Gold Gold nanoclusters Humans Hydrogen-peroxide Limit of detection Markers Metal nanoclusters Metal nanoparticles Nanopores Nanoporous anodic alumina Photoluminescence Pre-eclampsia Prediction Preeclampsia and endogli Preeclampsia and endoglin Pregnancy Risk Ultrasound Women
Resumen: Preeclampsia is a pregnancy-specific hypertensive syndrome recognized as the leading cause of maternal and fetal morbidity worldwide. Early diagnosis is crucial for mitigating its adverse effects, and recent investigations have identified endoglin as a potential biomarker for this purpose. Here, we present the development of a hybrid biosensor platform for the ultrasensitive detection of endoglin, aimed at enabling the early diagnosis of preeclampsia. This platform integrates the high surface area properties of nanoporous anodic alumina (NAA) with the unique optical characteristics of gold nanoclusters (AuNCs) to achieve enhanced detection capabilities. The NAA surface functionalized to promote attachment of AuNCs, which then was functionalized with specific antibodies to confer selectivity towards endoglin. Photoluminescence (PL) analysis of the biosensor demonstrated a linear detection range of 10-50 ng/mL, with a detection limit of 5.4 ng/mL and a sensitivity of 0.004 a.u./(ng/mL). This proof-of-concept study suggests that the NAA-AuNCs-based biosensing platform holds significant potential for the development of ultrasensitive, portable, and cost-effective diagnostic tools for preeclampsia, offering a promising avenue for advancing prenatal care.
Áreas temáticas: Analytical chemistry Astronomia / física Biomedical engineering Biotechnology Biotecnología Chemistry, analytical Ciências biológicas i Ciências biológicas iii Ciencias sociales Clinical biochemistry Engineering (miscellaneous) Instrumentation Instruments & instrumentation Materiais Medicine (miscellaneous) Nanoscience & nanotechnology Química
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: lluis.marsal@urv.cat akash.bachhuka@urv.cat
Identificador del autor: 0000-0002-5976-1408 0000-0003-1253-8126
Fecha de alta del registro: 2025-01-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Biosensors. 14 (12): 610-
Referencia de l'ítem segons les normes APA: Cantons, Josep Maria; Bachhuka, Akash; Marsal, Lluis F (2024). Sensing Platform Based on Gold Nanoclusters and Nanoporous Anodic Alumina for Preeclampsia Detection. Biosensors, 14(12), 610-. DOI: 10.3390/bios14120610
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications