Identifier: imarina:9266893
Authors:
Boutureira Martín, Omar
Abstract:
The covalent coupling of two biomolecules to each other (bioconjugation) or to a solid support (immobilization) is one of the cornerstones of omic sciences.1 Among numerous chemical strategies to attain this goal, the versatile Michael-type addition of amine and thiol groups to vinyl sulfones is an attractive methodology.2 The latter are excellent Michael acceptors because of the electron-poor nature of their double bond, owed to the sulfone’s electron-withdrawing capability that makes them good electrophiles.3, 4 All the conjugate additions with vinyl sulfones share a similar reaction pattern, namely, the addition to the Β-position of the sulfone. Accordingly, these reactions are well-established methods for creating Β-heterosubstituted.
Repositori URV