Polyurethanes based on fatty acids with improved biocompatibility

Identificador:  TDX:1139

Handle: https://hdl.handle.net/20.500.11797/TDX1139

Autors:  González Paz, Rodolfo Jesús

Resum:
The main objective of this thesis has been the development of new polyurethanes from renewable sources such as fatty acids, using 'click' chemistry in the synthesis of the corresponding diols and polyols. The first part of this study describes the preparation of monomers 'via' thiol-ene or thiol-yne coupling, characterization and properties of the synthesized polyurethanes. As the polymers from fatty acids derived from biological macromolecules and can be potentially biocompatible, the second part of this work is focused on the enhancement of polyurethanes biocompatibility through bioactive molecules functionalization strategies, for tissue engineering purposes. Three approaches have been investigated: blends of polyurethanes and gelatin; covalent surface modification of polyurethanes with collagen by plasma treatment; and ionic surface modification of polyurethanes with chondroitin sulfate by aminolysis treatment.