Regulación genético-nutricional del estado en folatos en una población adulta no expuesta a ácido fólico profiláctico y durante el embarazo

Identificador:  TDX:1299

Handle: https://hdl.handle.net/20.500.11797/TDX1299

Autors:  Bueno Fraile, Olalla

Resum:
Many polymorphisms involved in folate transport and metabolism can impair folate status, and the co-existence of certain polymorphisms with MTHFR 677 C>T could enhance the effect of this polymorphism on folate status. However, mandatory folic acid fortification of grain products in some countries could mask the effect of the genotype. A cross-sectional study with a representative sample of general population and a longitudinal pregnancy study were driven. We describe for the first time four couples of polymorphisms which are associated with higher risk of being in the low tertile of plasma or red cell folate and one polymorphism associated with lower risk of being in the low tertile of red cell folate. In pregnant women, we find that folic acid supplementation during the first trimester balances the deleterious effects of MTHFR 677TT genotype on red cell folate concentration.