Lipodistròfia en pacients infectats pel vih tractats amb fàrmacs antiretrovirals: determinants genètics i moleculars.

Identificador:  TDX:1937

Handle: https://hdl.handle.net/20.500.11797/TDX1937

Autors:  Saumoy Linares, Maria

Resum:
Lipodystrophy is a body fat redistribution condition. It is a common long term adverse effect in HIV-infected patients associated with antiretroviral drugs, HIV itself and genetic susceptibility. This doctoral thesis analyzes the effect of 3 molecules and their genetic variants in the pathogenesis of HIV-associated lipodystrophy in a case-control study. Expression (messanger RNA; mRNA) of these molecules in abdominal adipose tissue of HIV participants with and without lipodystrophy and in healthy controls was determined. Interleukin-6 mRNA was higher in adipose tissue of HIV-infected patients compared with healthy controls; its genetic variant -174 G>C was not associated with lipodystrophy. Peroxisome proliferator-activated receptor gamma (PPAR-γ) mRNA was decreased in patients with lipodystrophy, but no association between lipodystrophy and Pro12Ala polymorphism was found. Lipin was hiperexpressed in adipose tissue of HIV-infected patients; there was a positve association with insulin sensitivity and negative association with proinflammatory cytokines.