Actividad y eficacia experimental de fármacos antifúngicos frente a levaduras causantes de micosis sistémicas

Identificador:  TDX:2142

Handle:  https://hdl.handle.net/20.500.11797/TDX2142

Autors:  Thomson Morales, Pamela Evelyn

Resum:
Although therapies for fungal infections have improved much during last 10 years, infections by opportunistic fungus still are a serious threat, especially for immune-compromised patients. The low influence of these infections have complicated the adoption of effective therapeutic strategies, hence they’re associated with a high mortality rate. The goal of this thesis has been to contribute the development of experimental therapies alternative for opportunistic mycoses originated by emerging pathogens Saprochaete capitata, Cryptococcus albidus, Cryptococcus laurentii, Rhodotorula mucilaginosa and Saccharomyces cerevisiae. In vitro and in vivo evaluations were carried out and they have led us to propose new therapeutic alternatives for the infections caused by these pathogens.