Identificador: TDX:2373
Autors: Cabrera Vilanova, Maria Aránzazu
Resum:
Background: Morbid obesity is one of the most prevalent chronic metabolic diseases, considered an epidemic and a major public health problem. Comorbidities that diminish the quality and life expectancy is attached. Currently there are effective bariatric techniques accepted by the scientific societies. Gastric plication lately resurfaces, which aims to mimic the metabolic and restrictive effect of sleeve gastrectomy. There is controversy over the benefits and few experimental studies.
Goal: To determine Gastric Plication changes in weight, metabolism, hormones and histology, based on an experimental model of obesity, compared with sleeve gastrectomy.
Material and methods: There were used 3 groups of an experimental model of obesity (Sprague Dawley rats), to which a Gastric Plication, a Sleeve gastrectomy and a gastrotomy (Sham group) was performed. In all groups weight, intake, blood glucose levels, hormone levels were measured and gastric-liver biopsies were taken in surgeries and sacrifices.
This study is defined as applied research. Its main objective poses resolve practical issues and their development is aimed to improve existing processes. Its design is prospective, interventionist, randomized and experimental.
Results: The Sleeve Gastrectomy causes greaater weight losses in long term and greater reductions in blood glucose greater than Gastric plication. In Gastric Plication group, postoperatively, greater total intake is evidenced and cafeteria diet is preferred. A decrease in ghrelin and glucagon after gastrectomy is evidenced, unlike the Gastric plication group. Both techniques produce an improvement in hepatic steatosis and inflammation, and Gastric plication causes significant inflammation of the gastric submucosa.
Conclusions: We have obtained data supporting the theory that sleeve gastrectomy is more effective than Gastric plication in both weight loss and improvement of comorbidities.
Repositori URV