Aterosclerosi i citocines: influència de CCL2 i els seus receptors

Identificador:  TDX:2424

Handle: https://hdl.handle.net/20.500.11797/TDX2424

Autors:  Fibla Simó, Montserrat

Resum:
Chemokine (C-C motif) ligand 2 (CCL2) is a molecule quimioatraient leading monocyte inflammatory sites, key in inflammatory processes. CCL2 function occurs through binding to functional receptors (CCR2), also it binds to receptors atypical or silent chemokines (ACKRs), with ability to remove or sequester these chemokines. CCL2 concentration circulating in patients with chronic ischemia in the lower limb was measured and found to arteries of these patients have increased expression of CCL2 and chemokine receptor atypical compared to normal arteries. Asp42Gly polymorphism Association (rs12075) atypical DARC receptor (ACKR1) with the concentration of circulating CCL2 was analyzed, and was significantly increased with the severity and the presence of the disease; and was dependent rs12075 genotype (AA> AG> GG), indicating increased expression of chemokine receptors in the arteries of the AA subjects. Associations with genetic variants and the overpressure of atypical chemokine receptors in diseased arteries may have potential implications, CCL2 may represent a previously unrecognized factor that needs to be considered. As for the role of CCL2 in coronary artery disease, the goal was to investigate where and to what extent CCL2 and its receptors in affected arteries that have caused the patient's death is expressed. immunohistochemical expression of macrophages, CCL2 and associated receptors were significantly higher in diseased arteries was assessed. The most significant increases were in CCL2 and ACKR1. There were no correlations with the expression of CCL2, which was the only variable predictive accuracy of atherosclerosis. CCL2 expression was marginal in normal arteries and mainly restricted to cells • smooth muscle cells. Our data indicate that CCL2 is a potentially useful marker in diagnosis of atherosclerosis.