Estudi dels canvis en la distribució de les subclasses de lipoproteïnes i partícules romanents en diferents condicions associades a risc arterioscleròtic: més enllà del colesterol

Identificador:  TDX:2515

Handle: https://hdl.handle.net/20.500.11797/TDX2515

Autors:  González Muñoz, Marta

Resum:
Despite huge advances in the field of cardiovascular risk prevention, a significant proportion of heart attacks occur in individuals with a normal routine lipid profile. Advanced analysis by nuclear magnetic resonance (NMR), which determines the size and number of lipoprotein particles, and the determination of remnant lipoproteins (RLs) can help solve the methodological constraints presented by conventional lipid parameters. In this context we considered the study with advanced analysis, in patients with systemic lupus erythematosus (SLE) to respond to its high-risk atherosclerotic despite presenting a conventional minimally altered lipid profile. Moreover, in LES the prevalence of subclinical atherosclerosis at younger ages is greater than in the general population, meaning that age does not have a strong impact on the atherosclerotic process. Both age and body mass index (BMI) are known and are important risk factors for the atherosclerotic process, but they have never been studied from this point of view, in a population with an absence of any chronic disease. Finally, given that cholesterol transported for the fraction of remnant lipoproteins RLP has been considered an independent risk factor for atherosclerosis, it is important to know the particles composition. The conclusion is that advanced analysis of lipids and lipoproteins allows us to prove that the size and number of lipoproteins, together with LR, provide additional information on the effect of LES, age and BMI, in the pathogenic process of atherosclerosis, from that which is obtained by conventional lipid parameters; and what it is generally called RLs is not an homogeneous group particle and therefore it should not be talked about as such.