Avaluació de la qualitat analítica de diferents biomarcadors de l'estrès oxidatiu i la inflamació en una població sana

Identificador:  TDX:2596

Handle: https://hdl.handle.net/20.500.11797/TDX2596

Autors:  Sánchez Martos, Vanessa

Resum:
Biomarkers are measurable, methodologically valid and quantifiable biological parameters, indicators of health status and also related to pathophysiological processes. Biomarkers measurement requires the availability of accurate and reproducible analytical methods. This requirements are usually expressed as a standard deviation and the coefficient of variation. However, to determine the analytical quality of any laboratory analysis there exist other parameters such as relative coefficient of variation, systematic error, random error and total analytical error. Inflammation and oxidative damage are emerging the most contributors to degenerative diseases, cardiovascular diseases or cancer. The aim of this study is to establish the analytical quality degree of different biomarkers related to oxidative stress, inflammation and ferric profile in healthy population by calculating the relative coefficient of variation, the accuracy, the systematic error, random error and total analytical error. We concluded that the relative coefficient of variation, systematic error and total analytical error were better quality indicators than standard deviation and inaccuracy. Although the relative coefficient of variation was a good indicator of analytical quality, the establishment of the level of quality according to the inaccuracy, systematic error and total analytical error is excessive quality indicator for a research laboratory.