ANGPTL8 y su implicación en el embarazo, la diabetes y la obesidad

Identificador:  TDX:2820

Handle: https://hdl.handle.net/20.500.11797/TDX2820

Autors:  Martínez Pérez, Bruno

Resum:
This paper studies the role of ANGPTL8 in obesity and pregnancy. ANGPTL8 is a circulating protein produced mainly by the liver and which has been linked to adipogenesis and to the homeostasis of lipid and hydrocarbon metabolism. Given that obesity and pregnancy are two situations characterized by the presence of insulin resistance, in which there are alterations in the metabolism of both lipids and carbohydrates and in which changes occur in fatty deposits, we consider that it could be relevant to know the dynamics of the ANGPTL8 in these entities. In pregnancy, we observed that ANGPTL8 levels are higher than outside of pregnancy, reaching the maximum level in the first trimester of pregnancy. At the time of delivery, fetal ANGPTL8 levels are higher than those observed in maternal blood and show an association with birth weight and neonatal adiposity, being lower in neonates with adequate weight for gestational age and / or at birth. medium tertile of adiposity. In murine models, we showed that the expression of ANGPTL8 in brown adipose tissue of the mother and the fetus was parallel to that of UCP1, and in cell lines we observed that the expression of this protein increased during the browning process. In addition, when treating adipose tissue with ANGPTL8, the expression of brown adipocyte markers is promoted, suggesting a possible role as a promoter of browning. All these data suggest that ANGPTL8 could play a role in the regulation of fetal growth and adipogenesis in intrauterine life. On the other hand, we studied the levels of ANGPTL8 in patients with obesity with and without type 2 diabetes mellitus, and we observed that the circulating levels of ANGPTL8 were lower in obese patients with type 2 diabetes mellitus compared with obese patients without diabetes. In addition, we observed that one month after surgery, there was an increase in ANGPTL8 levels and that this increase was able to predict the remission of diabetes one year after surgery. Therefore, our studies suggest that ANGPTL8 would be involved in the physiology of pregnancy and in the etiopathogenesis of diabetes and obesity.