Taxonomía de hongos celomicetos de interés clínico

Identificador:  TDX:2821

Handle: https://hdl.handle.net/20.500.11797/TDX2821

Autors:  Valenzuela López, Nicomedes

Resum:
In the last three decades, medical mycology has demonstrated a special interest to opportunistic pathogenic fungi, which cause a wide range of infectious pathologies (from superficial and deep infections), mainly in immunocompromised individuals, which determines that these infections are often difficult to treat and, which is why they have a high associated mortality. Although coelomycetes fungi are frequently isolated from clinical specimens, the actual incidence of their species as infectious agents for humans is unknown. In the present study, 452 clinical and environmental isolates belonging to different genera of coelomycetes were characterized, morphologically and molecularly, in order to clarify their taxonomy and phylogenetic placement. The results obtained revealed the large diversity of species within the coelomycetes, with the Pleosporales as the most prevalent order (> 50% of total isolates), this allowed the publication of a large number of new taxa for science distributed among families, genera and species (more than 60 new species). The study of in vitro sensitivity of different genera of coelomycetes against antifungals showed that most of them are sensitive to different antifungal groups, and only, in particular, some isolates showed a relative resistance to the group of azoles, polyenes or echinocandins.