Estudio de propiedades fisicoquímicas de las lipoproteínas para una mejor predicción del riesgo residual

Identificador:  TDX:2843

Handle: https://hdl.handle.net/20.500.11797/TDX2843

Autors:  Rodríguez García, Marina

Resum:
Cardiovascular diseases are the main cause of death worldwide. Approximately, 30 - 40% of myocardial infarctions occur in situations with normal levels of total cholesterol and LDLc, so they cannot be explained by traditional risk factors. This situation creates the need to look for new risk factors through more exhaustive analysis. The factors analyzed are the diameter and particles number of lipoproteins, the net electric charge, the content and the components of LPS and the glycoforms of Apo CIII. The populations used are patients diagnosed with SLE, control participants and young, healthy women and men. The results obtained demonstrate the importance of exhaustive analysis in the search for new risk factors, since they favor the diagnosis of atherogenic lipid profiles. The diameter and particles number of lipoproteins help to identify an atherogenic lipid profile in situations of stress and anxiety. The net electric charge is influenced by stress and anxiety and, in patients with lupus, the net electric charge has an effect on the thickness of the carotid intima-media independent of the anthropometric characteristics, smoking and lipid profile. The Apo CIII glycoforms are also distributed in plasma and in lipoproteins; however, the LPS and its components do not. In addition, a great variety of correlations are obtained with different behaviors between these parameters and the lipid profile, as a function of the parameter and the lipoprotein where it is focated. Finally, Apo CIII glycoforms affect the amount of LPS and its components that are bound to lipoproteins. All this leads to the conclusion of the importance of carrying out exhaustive analyzes of the physical-chemical properties of lipoproteins, and the study of the interactions between them.