Cu(0) wire-mediated SET-LRP in biphasic systems and development of stimuli cleavable polymers

Identificador:  TDX:3309

Handle: https://hdl.handle.net/20.500.11797/TDX3309

Autors:  Moreno Guerra, Adrian

Resum:
Cu(0)wire-catalyzed SET-LRP has been postulated as one of the most versatile LRP techniques due to its operational simplicity which enables the construction of well-defined polymers and more complex architectures. In particular, the development of polymeric materials with suitable applications for medicine (e.g. polymeric nanoparticles able to encapsulate and release drugs) is a field of growing interest since they improve the poor solubility of hydrophobic drugs in aqueous media. However, their selective delivery under the application of different biological relevant stimuli still remains challenging. The main objective of this thesis is to investigate the Cu(0)wire-catalyzed SET-LRP in “programmed” biphasic systems and to explore the potential and limitations of this methodology with the ultimate goal of obtaining well-defined polymers with complex architectures and maximum end-group fidelity. Eventually, the application of biphasic SET-LRP and other polymerization techniques has been used for the synthesis of stimuli cleavage polymers and their potential application as drug delivery systems has been studied.