La implicación de las quimiocinas y las adipoquinas en la respuesta inmune discordante en la infección por el VIH

Identificador:  TDX:4186

Handle: https://hdl.handle.net/20.500.11797/TDX4186

Autors:  Yeregui Etxebarria, Elena

Resum:
Since the start of antiretroviral treatment, mortality and morbidity due to HIV have drastically decreased, but even so, a non-negligible percentage of people living with HIV (PLHIV) do not manage to recover their T-CD4+ counts despite correct virological suppression. The mechanisms involved in this poor immune recovery are multiple and complex, and until now they have not been fully elucidated. The objective of this thesis is to determine the involvement of chemokines and adipokines in the discordant immune response. Both chemokines and adipokines are cytokines that play an essential role in the immune response, and their secretion and production is altered in HIV infection, which has repercussions on immune recovery. To study the effect of these cytokines on the poor immune response in HIV, two studies were carried out, which have resulted in two scientific publications. In both studies, patients with HIV were recruited and were classified according to their baseline T-CD4+ counts, and later according to their degree of immune recovery. Chemokine concentrations, their genetic variants, and adipokines were analyzed both at baseline and during follow-up. The results obtained conclude that chemokines and adipokines are involved in immune recovery and that they can serve as prognostic markers of a discordant immune response.