Impact of fatty acid metabolism in breast cancer peritumoral tissue. Clinical and pathogenic aspects

Identificador:  TDX:4220

Handle: https://hdl.handle.net/20.500.11797/TDX4220

Autors:  Adriá Cebrián, Jose

Resum:
Breast cancer is the most common cancer in women and the second cancer with more related deaths. Knwoledge og the behavior of tumor cells within their microenvironment might open new research possibilities and new therapeutic tarjets in the future. In this doctoral thesis, we have demonstrated how diverse factors that are released by the adipose tissue, especially FABP4, are able to enhance the diverse cancer hallmarks. Moreover, we have demonstrated the birectionallity of the microenvironemnt crosstalk, as well as that the lipid transfer and their metabolism is different in the different submolecular BC types, thus might explain their different malignance grades. Tne immune system, as an element of the tumor microenvironment is altered by this crosstalk, by activating the pro-inflammatory pathways. This is translate to an enhancement of the pro-inflammatory status of BC patients. Interestingly, this status is positively correlated with the increment of FABP4 serum levels in BC patients. Moreover, this study has demonstrated that the liporpotein profile is notably altered in BC patients, where there is a cholesterol and triglycerides enrichement within the different lipoproteins. These changes have been positively correlated with the inflammatory status of our BC patients. The serum LMWMs analysis by 1H-NMR demonstrated that there was a disregulated serum levels of different aminoacids. Knowledge of new biomarks would open new diagnosis methods, that might help in an earliest diagnosis, hence in the BC patients’ prognosis.