Targeting Des1: Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AF2-assisted structural insights reveal PR280 as a potent inhibitor

Data: 2024-04-26; 2024-05-31T11:20:22Z; 2024-05-31T11:20:22Z

Departament/Institut: Departament de Química Analítica i Química Orgànica; Universitat Rovira i Virgili.

Idioma: eng

Identificador: http://hdl.handle.net/10803/691255

Font: TDX (Tesis Doctorals en Xarxa)

Autor: Rivero Prieto, Pablo

Director: Díaz Giménez, María Yolanda; Matheu Malpartida, María Isabel

Format: application/pdf; 335 p.

Editor: Universitat Rovira i Virgili

Paraula Clau: cyclopropenone; Ceramide; ciclopropenona; AlphaFold; Ceramida

Títol: Targeting Des1: Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AF2-assisted structural insights reveal PR280 as a potent inhibitor

Matèria: 547; 54; 5; 00; Ciències; cyclopropenone; Ceramide; ciclopropenona; AlphaFold; Ceramida