Influència de paraoxonasa-1 (pon1) en l'evolució de la infecció pel virus de la immunodeficiència humana-1 i les seves complicacions metabòliques

Identificador:  TDX:525

Handle: https://hdl.handle.net/20.500.11797/TDX525

Autors:  Parra Pérez, Sandra

Resum:
HIV infection has become a chronic disease since introduction of antiretroviral treatments. Despite the decline in mortality, the incidence of metabolic complications related to treatment and the infection itself are becoming more relevant. HIV infection promotes a pro-oxidative status that favors viral replication and the emergence of the metabolic disorders such as atherosclerosis and lipodystrophy. Atherosclerosis is recognized as a chronic inflammatory disease. The paraoxonase-1 (PON1) is an enzyme bound to high-density lipoprotein (HDL), which confers high antioxidant properties. Although its physiological sustrat is not yet known, it has been studied its protective role in several chronic diseases with an increase in oxidative stress and atherosclerosis. For this reason we believe is of interest to investigate the possible role of this antioxidant enzyme in the immunological and the virological evolution of HIV infection and in the apparition of metabolic complications such as atherosclerosis.