Peroxidación lipídica y factores de riesgo cardovascular

Identificador:  TDX:648

Handle:  https://hdl.handle.net/20.500.11797/TDX648

Autors:  Plana Gil, Núria

Resum:
We have analysed the plasma and LDL oxidation susceptibility in individuals with and without the presence od cardiovascular risk factors. OBJECTIVES: To study the lipid peroxidation levels in plasma and LDL fraction in subjects with and without DHD risk factors: Hipercholesterolemia, Obesity, Diabetis, Odl age and Tabacco. To study the modification induced in the lipid peroxidation levels in plasma and LDL in hypercholesterolemia subjects after Probucol treatment and in obese subjects after a very low calory diet. SUBJECTES AND METHODS: Were recruited 83 patients attending to the metabolic Unit of Sant Joan Hospital (33 hypercholesterolemia, 25 diabetic, 25 obese). As control group were recruited 93 apparenty healthy individuals. A complete lipoprotein profile was determined by ultracentrifugation in them all. Thiobarbituric acid reacting substances were measured inn plasma and LDL fraction. In the hypercholesterolemia patients similar measurement were also carried out after 3 and 6 month if Probucol treatment. In the morbide obesity patients TBARS were analysed after 4 weeks on a very calory diet. RESULTS: Hipercholesterolemia patients had a higher concentration of TBARS both in plasma and LDL that the normalcholesterolemia subjects (7.69±2.19 vs 5.14±1.74 p<0.01, 3.19±1.07 vs 2.19±0.70 p<0.01). The TBARS values were normalized after Probucol treatment reaching the control group values (p<0.01 compared to basal values). Diabetic patients also had higher plasma and LDL oxidation values tham the control group (6.89±1.52 vs 5.14±1.74 p<0.01, 2.60±0.64 vs 2.19±0.70 p<0.05). In the morbid obesity woman group TBARS were higher tham in decreased after the diet period although remained higher tham in controls. The TBARS values were higher in the elderly subjects >65 years resp