Lligands catalítics modulars derivats d'epòxids enantiopurs: aminoalcohols, aminotiols i isòsters peptídics

Identificador:  TDX:822

Handle: https://hdl.handle.net/20.500.11797/TDX822

Autors:  Subirats Benet, Silvia

Resum:
The thesis ' Lligands catalítics modulars derivats d'epòxids enantiopurs: aminoalcohols, aminotiols i isòsters peptídics' describes the enantioselective synthesis of enantiopure ligands starting from different enantiopure epoxides.<br/>Enantioselective and regioselective epoxide ring opening with amines and posterior modifications allowed the generation of different enantiopure aminoalcohols and aminothiols. These molecules were used as ligands in catalytic asymmetric addition of acetylenes to aldehydes. Propargylic alcohols were synthesised with high enantioselectivities and high yields.<br/>Enantioselective and regioselective enantiopure epoxide ring opening with aminoesthers generated enantiopure dipeptide isostheres. With proper late molecule modification modular tripeptide isostheres were synthesised.<br/>These molecules were used as ligands in catalytic asymmetric cianosilylation and in catalytic asymmetric hydrogen transfer reaction. Both catalytic reactions were performed with high enantioselectivities and high yields.