1,3- DIPHOSPHITE LIGANDS WITH FURANOSIDE BACKBONE: A POWERFUL TOOL IN ASYMMETRIC CATALYSIS

Identificador:  TDX:878

Handle: https://hdl.handle.net/20.500.11797/TDX878

Autors:  Gual Gozalbo, Aitor

Resum:
Asymmetric catalysis is part of the asymmetric synthesis and makes possible the transformation of a pro-chiral or racemic substrate into a chiral product using catalytic amounts of the compounds which contain the chiral information. The design of new ligands is perhaps the most crucial step to achieve the highest levels of reactivity and selectivity. Carbohydrates are the most prominent members of the 'chiral pool'.This thesis focus on the development and application in asymmetric catalysis of new 1,3-diphosphite with carbohydrate backbone. These ligands were successful applied in the Rh-asymmetric hydroformylation of monosubstituted, disubstituted internal and 1,1´-disubstituted alkenes.The effect of the structural modification of these 1,3-diphosphite ligands on the catalytic results of the Pd-allylic alkylation of phenyl-allyl compounds was also studied in this thesis. Finally, the 1,3-diphosphites ligands were applied to stabilize metal nanoparticles. These nanocatalysts were tested in the hydrogenation of pro-chiral o- and m-methylanisole.