Asymmetric catalysis and molecular recognition using different platforms: homogeneous systems, functionalized polymers and magnetic nanoparticles

Identificador:  TDX:946

Handle: https://hdl.handle.net/20.500.11797/TDX946

Autors:  Mendoza Muniz, Carolina

Resum:
In this work three new di-platinum(II) thiolato-bridged complexes [(dppp)Pt{-S(CH2)nNHC(=O)NHR}]2(OTf)2 (n = 2, 3; R = Et, Ph) have been synthesized, fully characterized and studied as synthetic receptors for anionic species. The binding of anions has been quantitatively determined by 1H NMR spectroscopy and in a qualitative fashion by an indicator displacement assays. These studies have shown the receptors to be selective for H2PO4-. Cobalt and magnetite magnetic nanoparticles have been prepared and functionalized with a wide range of structures, namely crown ether type macrocycles, organocatalysts and -cyclodextrin. The nanoparticles functionalized with crown ether were used in the extraction of Pb2+ from aqueous and organic solutions. -cyclodextrin functionalized nanoparticles were used as carriers of organocatalysts via non-covalent interactions, and were applied in the asymmetric version of the aldol reaction in aqueous media. Finally, L-hydroxyproline and (S)-α,α-diphenylprolinol trimethylsilyl ether functionalized nanoparticles were also prepared and investigated as catalysts in asymmetric aldol and Michael reactions respectively.