Inflamació i oxidació en la infecció pel virus de la immunodeficiència humana: modificacions de les lipoproteïnes d'alta densitat

Identificador:  TDX:961

Handle: https://hdl.handle.net/20.500.11797/TDX961

Autors:  Aragonés Bargalló, Gerard

Resum:
Our proposal has explored for the first time the effect of human immunodeficiency virus (HIV)- infection on high-density lipoprotein (HDL) particles, and we determined their involvement in the course of infection itself and the development of atherosclerosis in order to design novel therapeutic strategies. Our results show how the chronic oxidant and inflammatory status associated with infection plays a central role in the onset of metabolic disorders and the development of subclinical atherosclerosis in these patients. Concretely, using both, chromatographic and proteomic techniques, we observed how the increased levels of gammaglobulin, pro-inflammatory molecules and acute phase reactants in the plasma of these patients induced metabolism alterations and modifications on the distribution and composition of HDL particles, suggesting that the monitoring of HDL particles in these patients should not be only based on the determination of the concentration of cholesterol content, but must include the determination of other parameters associated with particle quality, and therefore the functionality, of HDL particles