Inflamació com a nexe d'unió entre obesitat i complicacions metabòliques: esteatosi hepàtica

Identificador:  TDX:976

Handle: https://hdl.handle.net/20.500.11797/TDX976

Autors:  Rull Aixa, Anna

Resum:
Inflammation has been traditionally regarded as a defense mechanism, closely linked to the survival of the species for their ability to fight infections or restore the damage. However, a state of chronic inflammation produced a completely opposite effect, which is associated with tissue and organ malfunction. The aim of this work is the study of monocyte chemoattractant protein-1 (MCP-1), a protein described by its role in attracting monocytes to atherosclerotic lesions, which may also play an important role in metabolism. The results show that MCP-1 is involved in the control of lipids and glucose metabolism. Hepatic MCP-1 is over-expressed by diet and contributes to the development and progression of fatty liver disease (NASH) in LDLr-/- model. Indeed, the latest study shows that metabolomic changes in the liver can help us to understand the NASH progression.