Repositori URV

Identifier: TDX:1167

Handle: https://hdl.handle.net/20.500.11797/TDX1167

Authors:
Diego Cabanes, Cinta de

Abstract:
The infection of influenza virus has a high incidence in young people and children rather than the elderly, but the morbidity and mortality associated with influenza virus infection increases with age, especially in patients with concomitant pathology . In this thesis, we followed a cohort of 11,240 people over 65 in Tarragona, assigned to eight basic health areas (ABS) for 4 years (between January 2002 and April 2005), studying the relationship between receipt the vaccine (VAG) and the winter mortality in the whole population aged 65 years and in subgroups of people with chronic diseases, such as chronic obstructive pulmonary disease (COPD), people with chronic heart disease and diabetes mellitus (DM). Four articles were used for the realization of this thesis 1- Ángel Vila-Córcoles, Teresa Rodríguez, Cinta de Diego, Olga Ochoa, Amparo Valdivieso, Elisabet Salsench, Xabier Ansa, Waleska Badía, Neus Saún, EPIVAC Study Group. Effect of influenza vaccine status on winter mortality in Spanish community-dwelling elderly people during 2002–2005 influenza periods. Vaccine. 2007 Sep 17;25(37-38):6699-707. This study assessed the relationship between the reception of conventional inactivated influenza vaccine and winter mortality in a prospective cohort that included 11,240 Spanish community-dwelling elderly individuals followed from January 2002 to April 2005. Annual influenza vaccine status was a time-varying condition and primary outcome was all-cause death during study period. Multivariable Cox proportional- hazard models adjusted by age, sex and co-morbidity were used to evaluate vaccine effectiveness. Influenza vaccination was associated with a significant reduction of 23% in winter mortality risk during overall influenza periods. The attributable mortality risk in n