Highly modular p -op ligands for rhodium- and iridium-mediated asymmetric hydrogenations

Identifier:  TDX:1196

Handle: https://hdl.handle.net/20.500.11797/TDX1196

Authors:  Núñez Rico, José Luis

Abstract:
In the present PhD Thesis, we havebroadened the application of chiral rhodium complexes derived from our highly modular POP ligands in asymmetric hydrogenation. Outstanding results were observed in the enantioselective hydrogenation of a wide array of substrates, as well as in the hydrogenation of strategically devised prochiral alkenes leading to advanced intermediates of active pharmaceutical ingredients. We also evaluated the coordination of POP ligands to iridium precursors and studied their application to the hydrogenation of C=N-containing compounds. We developed activation strategies for substrate activation, which involved using Brønsted acids as additives. Isotopic labeling experiments allowed us to gain a deep understanding of the mechanism of the asymmetric hydrogenation of substituted quinolines mediated by our iridium catalysts.