Analysis of polymerisation / aggregation processes by nir chemical imaging and ftir spectroscopy

Identifier:  TDX:1253

Handle: https://hdl.handle.net/20.500.11797/TDX1253

Authors:  Martí Aluja, Idoia

Abstract:
The overall objective of this thesis is to develop analytical methods based on infrared spectroscopy and chemometric techniques to analyse two different processes that involve a state change from a liquid to a solid. The first studied process is a polymerisation process and it was followed by near-infrared chemical imaging (NIR-CI). The chemometric treatment of the images acquired allowed evidencing a tautomer’s equilibrium of one of the reagents. The second studied process was insulin aggregation. Aggregation process was monitored infrared spectroscopy (IR), and different methods were established which allowed on the one hand the assessment of the effect of antiretroviral drugs on the process; and on the other hand, the influence of biochemical variables on the process.